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Method and apparatus for detecting nucleotides

  • US 9,228,976 B2
  • Filed: 09/27/2013
  • Issued: 01/05/2016
  • Est. Priority Date: 04/24/2000
  • Status: Expired due to Term
First Claim
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1. A system comprising:

  • a substrate defining a pore extending through the substrate and including at least three voltage carrying regions disposed along the pore;

    a plurality of interconnects, each interconnect of the plurality of interconnects uniquely connected to a voltage carrying region of the at least three voltage carrying regions;

    one or more power supplies in electrical communication with the plurality of interconnects and defining potential differences between at least two pairs of voltage carrying regions selected from the at least three voltage carrying regions; and

    one or more meters to measure a difference in electrical characteristics of each of the at least two pairs of voltage carrying regions, the electrical characteristic indicative of a base sequence of a nucleic acid.

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