Information notification sample processing system and methods of biological slide processing

• US 9,229,016 B2
• Filed: 06/17/2014
• Issued: 01/05/2016
• Est. Priority Date: 12/20/2002
• Status: Active Grant

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Dako Denmark A/S (Agilent Technologies, Inc.)
• Inventors: Feingold, Gordon, Key, Marc, Favuzzi, John, Welcher, Rosanne
• Primary Examiner(s): Barbee, Manuel L
• Application Number:
  US14/306,606
• Publication Number:
  US 20140356935A1
• Time in Patent Office: 567 Days
• US Class Current: 1/1
• CPC Class Codes: G01N 1/30 Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
• CPC Class Codes: G01N 1/31 Apparatus therefor
• CPC Class Codes: G01N 1/312 for samples mounted on planar substrates
• CPC Class Codes: G01N 2035/00039 Transport arrangements specific to flat sample substrates, e.g. pusher blade
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00306 Housings, cabinets, control panels (details)
• CPC Class Codes: G01N 2035/00326 Analysers with modular structure
• CPC Class Codes: G01N 2035/00366 Several different temperatures used
• CPC Class Codes: G01N 2035/00376 Conductive heating, e.g. heated plates
• CPC Class Codes: G01N 2035/00435 Refrigerated reagent storage
• CPC Class Codes: G01N 2035/00881 network configurations
• CPC Class Codes: G01N 2035/00891 Displaying information to the operator
• CPC Class Codes: G01N 2035/009 alarms, e.g. audible
• CPC Class Codes: G01N 2035/0091 GUI [graphical user interfaces]
• CPC Class Codes: G01N 35/00712 Automatic status testing, e.g. at start-up or periodic
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G01N 35/00871 Communications between instruments or with remote terminals
• CPC Class Codes: G01N 35/0092 Scheduling
• CPC Class Codes: G01N 35/0099 comprising robots or similar manipulators robots per se B25J
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10S 901/02 : Arm motion controller
• CPC Class Codes: Y10S 901/41 : Tool
• CPC Class Codes: Y10T 436/11 : Automated chemical analysis
• CPC Class Codes: Y10T 436/112499 : with sample on test slide
• CPC Class Codes: Y10T 436/113332 : with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 : with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/114998 : with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/25 : including sample preparation
• CPC Class Codes: Y10T 436/2575 : Volumetric liquid transfer

Abstract

A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Claims

1. An automated immunohistochemistry and in-situ hybridization sample processing system comprising:

a control system configured to receive a protocol via a network, said control system being configured to at least partially process at least one biological sample arranged on a first slide, and further configured to receive and process a second slide;

a robotic motion system responsive to said control system configured to move a robotic member and to dispense fluids from the robotic member, wherein receiving the second slide does not interrupt fluid dispensing of the robotic member, and wherein dispensing fluids includes dispensing a buffering agent;

a multiple event scheduler configured to schedule a plurality of sample process operations based on the protocol, wherein the sample process operations include both immunohistochemistry process operations and in-situ hybridization process operations, said robotic motion system being at least in part responsive to the multiple event scheduler;

an operationally-influential exteriorly-consequential information monitor configured to monitor usage information of the sample processing system;

and an exteriorly-consequential information notice element responsive to said operationally-influential exteriorly-consequential information monitor, said exteriorly-consequential information notice element configured to communicate via the network the operationally-influential exteriorly-consequential information.

2. The automated sample processing system of claim 1, wherein said multiple event scheduler is configured to schedule process steps to process a first slide at a first temperature for a first scheduled time period according to an in-situ hybridization protocol and to process a second slide at a second temperature for a second scheduled time period according to an immunohistochemistry protocol.

3. The automated sample processing system of claim 2, wherein the first temperature for in-situ hybridization is between 90°

C. and 100°

C. and the second temperature for immunohistochemistry is room temperature.

4. The automated sample processing system of claim 1, further comprising a historical usage information monitor, wherein the stainer also includes at least one reagent container.

5. The automated sample processing system of claim 4, further comprising an automatic predictive need notice element that determines a need for replenishing reagent of the at least one reagent container.

6. The automated sample processing system of claim 5, wherein said operationally-influential exteriorly-consequential information monitor comprises a predictive usage information element.

7. The automated sample processing system of claim 6, wherein said predictive usage information element comprises an order lead time information data element, a reagent order lead time information data element, or a maintenance lead time information data element.

8. The automated sample processing system of claim 7, wherein said exteriorly-consequential information notice element comprises an automatic operator exteriorly-consequential information notice element, an automatic administrator exteriorly-consequential information notice element, an automatic supplier exteriorly-consequential information notice element, or an automatic manufacturer exteriorly-consequential information notice element.

9. The automated sample processing system of claim 1, wherein

the control system is further configured to receive a second protocol via the network;

the multiple event scheduler is further configured to schedule a second plurality of sample process operations based on the second protocol, and

the exteriorly-consequential information notice element is configured to communicate via the network information regarding the insertion of the second slide and of a need for replenishing reagent of the at least one reagent container.

10. The automated sample processing system of claim 9, wherein the control system is further configured to receive at least one new reagent container, and wherein receiving the at least one new reagent container does not interrupt fluid dispensing of the robotic member.