Satiety

• US 9,233,075 B2
• Filed: 08/09/2006
• Issued: 01/12/2016
• Est. Priority Date: 08/09/2005
• Status: Expired due to Fees

• Current Assignee: Tylerton International Inc.
• Original Assignee: MetaCure Limited (MetaCure (USA), Inc.)
• Inventors: Rousso, Benny, Ben-Haim, Shlomo
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): EBRAHIM, NABILA G
• Application Number:
  US11/990,211
• Publication Number:
  US 20090098198A1
• Time in Patent Office: 3,443 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 5/0036 Intragastrical devices
• CPC Class Codes: A61K 9/4808 characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release capsules filled with granules or microparticles A61K9/16; filled with microcapsules or coated microparticles A61K9/50; with mixture of different granules, microcapsules, (coated) microparticles A61K9/5084

Abstract

A capsule for suppressing appetite, comprising:

• a) a shell which dissolves in the stomach; and
• b) a plurality of elements inside the shell, which elements expand inside the stomach, after the shell dissolves, to form a connected mass with an envelope volume greater than the total volume of the elements, and at least 3 times the volume of the capsule.

Claims

1. A capsule for suppressing appetite, comprising:

a) a shell which dissolves in the stomach; and

b) at least one folded mechanical structure formed from natural vegetable pieces, wherein said at least one folded mechanical structure comprises;

a plurality of elements, and

a plurality of joints joining ends of said plurality of elements to define a plurality of voids between said plurality of elements,

wherein a natural fibrous structure of said natural vegetable pieces is preserved through a processing of said at least one folded mechanical structure, said processing comprising;

freeze drying,

folding thereby collapsing said plurality of voids, and

packing said at least one folded mechanical structure into said shell, wherein said plurality of elements and said plurality of joints expand inside the stomach;

after said shell dissolves to regain at least some of their original shape and unfold said compressed at least one folded mechanical structure redefining said plurality of voids.

2. A capsule according to claim 1, wherein the elements expand inside the stomach, after the shell dissolves, to form a mass with an expanded volume at least 3 times the volume of the capsule.

3. A capsule according to claim 2, wherein the expanded volume is at least 5 times the volume of the capsule.

4. A capsule according to claim 3, wherein the expanded volume is at least 10 times the volume of the capsule.

5. A capsule according to claim 1, wherein the elements consist of material substantially all of which leaves the stomach of a normal person in less than 12 hours.

6. A capsule according to claim 5, wherein substantially all of the material leaves the stomach in less than 9 hours.

7. A capsule according to claim 6, wherein substantially all of the material leaves the stomach in less than 6 hours.

8. A capsule according to claim 1, wherein the elements individually expand when they absorb fluid inside the stomach.

9. A capsule according to claim 1, wherein the elements comprise a food material approved for human consumption.

10. A capsule according to claim 9, wherein the food material comprises a freeze-dried vegetable.

11. A capsule according to claim 10, wherein the material comprises between 6% and 10% water by weight.

12. A capsule according to claim 1, wherein the elements comprise an inert non-food material.

13. A capsule according to claim 1, wherein said at least one folded mechanical structure is in a collapsed state when it is inside the shell, and which unfolds to a less collapsed state when it is released from the shell.

14. A capsule according to claim 13, wherein the expansion of said at least one folded mechanical structure is due at least partly to the removal of constraining forces exerted on said at least one folded mechanical structure by the shell.

15. A capsule according to claim 13, wherein the expansion of said at least one folded mechanical structure is at least partly triggered by exposure to water.

16. A capsule according to claim 15, wherein the expansion of said at least one folded mechanical structure is due at least partly to the absorption of fluid, which makes said at least one folded mechanical structure more rigid.

17. A capsule according to claim 15, wherein the expansion of said at least one folded mechanical structure is due at least partly to the absorption of fluid which makes the individual elements unfold.

18. A capsule according to claim 13, wherein said at least one folded mechanical structure corresponds to an array of polyhedrons;

with each element corresponding to an edge of one or more of the polyhedrons.

19. A method of inducing satiety in a patient, comprising feeding the patient one or more capsules according to claim 1.

22. A capsule according to claim 1, wherein the elements retain enough of said fibrous structure so that they are elastic at least when they absorb fluid inside the stomach after the shell dissolves.

23. A capsule according to claim 22, wherein the elements retain enough of said fibrous structure so that they are elastic when they are inside the shell.

24. A capsule according to claim 4, wherein the expanded volume is at least 20 times the volume of the capsule.

25. A capsule according to claim 1, wherein the elements retain enough of their mechanical structure so that the elements themselves expand by a factor of 4 in volume, when they absorb fluid in the stomach after the shell dissolves.

26. A capsule according to claim 1, wherein the elements themselves expand to at least 70% of the original volume of the vegetable pieces, when they absorb fluid in the stomach after the shell dissolves.

27. A capsule according to claim 1, wherein the elements are each at least about 0.5 mm in diameter when they are inside the shell.

28. A capsule according to claim 15, wherein the expansion of said at least one folded mechanical structure is due at least partly to the absorption of fluid, which makes said at least one folded mechanical structure more elastic.

29. A capsule according to claim 1, wherein the vegetable pieces comprise pieces of fruit.

30. A capsule according to claim 1, wherein said fibrous structure retains its elasticity when its water content is reduced to 10% by weight.

31. A capsule according to claim 1, wherein the vegetable pieces comprise digestible material.

33. A capsule according to claim 1, wherein at least some of said voids are between said natural vegetable pieces.

34. A capsule according to claim 1, wherein at least some of said voids are within said natural vegetable pieces.

20. A method of manufacturing capsules of expandable material for inducing satiety, comprising:

a) freeze-drying at least one folded mechanical structure formed from edible vegetable pieces comprising a fibrous structure to a moisture content less than 5%;

b) humidifying said at least one folded mechanical structure to a water content of at least 6% by weight, thereby making said at least one folded mechanical structure elastic;

c) folding said at least one folded mechanical structure; and

d) putting said at least one folded mechanical structure into a shell of a capsule small enough to swallow;

wherein the shell is configured to dissolve in the stomach, and said at least one folded mechanical structure is configured to unfold in the stomach sufficiently to suppress or reduce appetite, and wherein said at least one folded mechanical structure inside has shell has a preserved said fibrous structure.

21. A method according to claim 20, also including forming the vegetable pieces into shapes.

32. A capsule for suppressing appetite, comprising:

a) a shell which dissolves in the stomach; and

b) at least one folded mechanical structure inside said shell formed from natural vegetable pieces, wherein said at least one folded mechanical structure comprises a plurality of elements that define a plurality of voids between said plurality of elements formed by removing material from a block of natural vegetable material, wherein said natural vegetable pieces are dehydrated and preserve an original fibrous structure of said natural vegetable pieces.