Methods and compositions for treating pain
First Claim
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1. An inhalable, analgesic composition comprising microparticles of a diketopiperazine and a peptide comprising less than 20 amino acids;
- wherein said composition is effective at relieving pain, wherein the peptide is an opioid receptor agonist.
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Abstract
Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
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Citations
25 Claims
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1. An inhalable, analgesic composition comprising microparticles of a diketopiperazine and a peptide comprising less than 20 amino acids;
- wherein said composition is effective at relieving pain, wherein the peptide is an opioid receptor agonist.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- 17. A method for treating pain, comprising administering to a subject in need of treatment a therapeutically effective amount of an inhalable analgesic composition comprising microparticles of a diketopiperazine and a peptide comprising less than 20 amino acids using a dry powder drug delivery system, wherein the peptide is an opioid receptor agonist.
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23. An inhalable analgesic composition comprising 3,6-bis(N-X-4-aminobutyl)-2,5-diketopiperazine wherein X is fumaryl or a pharmaceutically acceptable salt thereof, and a synthetic peptide having the amino acid sequence:
- (D)Phe-(D)-Phe-(D)Ile-(D)Arg-NH2 (SEQ ID NO;
1) or (D)Phe-(D)Phe-(D)Nle-(D)Arg-NH2 (SEQ ID NO;
2). - View Dependent Claims (24, 25)
- (D)Phe-(D)-Phe-(D)Ile-(D)Arg-NH2 (SEQ ID NO;
Specification