Molecular imaging vial transport container and fluid injection system interface

• US 9,233,776 B2
• Filed: 03/13/2013
• Issued: 01/12/2016
• Est. Priority Date: 06/07/2012
• Status: Expired due to Fees

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Bazala, Jason L, Kaintz, Ryan C
• Primary Examiner(s): Wiest, Philip R
• Assistant Examiner(s): KLEIN, BENJAMIN JACOB
• Application Number:
  US13/800,194
• Publication Number:
  US 20130331810A1
• Time in Patent Office: 1,035 Days
• US Class Current: 1/1
• CPC Class Codes: A61J 1/1412 Containers with closing means, e.g. caps
• CPC Class Codes: A61J 1/16 Holders for containers
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61N 2005/1021 Radioactive fluid
• CPC Class Codes: A61N 2005/1094 Shielding, protecting against radiation
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy

Abstract

A pharmaceutical transport container includes a first body portion adapted to receive at least a portion of a pharmaceutical vial, a second body portion removably engaged with the first body portion to fully enclose the vial, and a flexible ring positioned in an interior cavity of the second body portion and configured to flex between a relaxed state and a radially-outward extended state. The pharmaceutical transport container may also include a removable end cap having a receiving chamber to receive the first body portion, and/or a guide tab extending from an exterior surface of the second body portion to engage a guide slot defined in a fluid injection system docking station, whereby the transport container translates axially and rotationally into the docking station to establish a fluid connection between the vial and a fluid connector mechanism or element disposed within the docking station.

Claims

1. A pharmaceutical transport container, comprising:

a first body portion adapted to receive at least a portion of a pharmaceutical vial and defining an opening for establishing fluid communication with the vial, and comprising a proximal end;

a second body portion engageable with the first body portion to fully enclose the vial, the second body portion having a distal end engageable with the proximal end of the first body portion and a closed proximal end, and defining an interior cavity therebetween; and

a flexible ring positioned in the interior cavity of the second body portion and configured to flex between a relaxed state and a radially-outward extended state;

wherein the second body portion is adapted to cooperate with a receiving docking station of a fluid injection system to establish a fluid connection between the vial and a fluid connector element disposed within the docking station as the second body portion is inserted axially into the docking station, and

wherein insertion of the first body portion into the interior cavity of the second body portion causes the flexible ring to deform from the relaxed state to the extended state thereby allowing the proximal end of the first body portion to be inserted therethrough, and after such insertion the flexible ring returns to the relaxed state to secure a removable engagement between the first body portion and the second body portion.

2. The pharmaceutical transport container of claim 1, further comprising at least one guide tab extending radially from an exterior surface of the second body portion or within the docking station, the at least one guide tab configured to engage at least one guide slot defined in the exterior surface of the second body portion or defined within the receiving docking station, such that engagement of the at least one guide tab with the at least one guide slot causes the second body portion to translate axially into the docking station to establish the fluid connection between the vial and the fluid connector element disposed within the docking station as a result of the axial translation.

3. The pharmaceutical transport container of claim 2, wherein the at least one guide slot is helical.

4. The pharmaceutical transport container of claim 1, wherein the flexible ring is elliptically-shaped.

5. The pharmaceutical transport container of claim 1, wherein the first body portion comprises a radially-outward extending rim cooperating with the flexible ring to cause a radial deformation of the flexible ring.

6. The pharmaceutical transport container of claim 5, wherein the radially-outward extending rim comprises an outer diameter greater than an inside distance across a minor axis of the flexible ring.

7. The pharmaceutical transport container of claim 1, wherein the first body portion defines a proximally extending wall configured to receive and surround a body of the vial and being receivable within the interior cavity of the second body portion.

8. A pharmaceutical transport container, comprising:

a first body portion adapted to receive at least a portion of a pharmaceutical vial and defining an opening for establishing fluid communication with the vial, and comprising a proximal end;

a second body portion engageable with the first body portion to fully enclose the vial, the second body portion having a distal end engageable with the proximal end of the first body portion and a closed proximal end and defining an interior cavity therebetween; and

a flexible ring positioned in the interior cavity of the second body portion and configured to flex between a relaxed state and a radially-outward extended state,

wherein insertion of the first body portion into the interior cavity of the second body portion causes the flexible ring to deform from the relaxed state to the extended state thereby allowing the proximal end of the first body portion to be inserted therethrough, and after such insertion the flexible ring returns to the relaxed state to secure a removable engagement between the first body portion and the second body portion.

9. The pharmaceutical transport container of claim 8, further comprising a removable end cap comprising an open proximal end, a closed distal end, and a receiving chamber to receive the first body portion therein to cover the opening and at least one guide tab extending radially from an exterior surface of the second body portion or within the receiving chamber of the end cap, the at least one guide tab engageable within at least one guide slot defined in the exterior surface of the second body portion or within the receiving chamber, the at least one guide slot oriented such that engagement of the at least one guide tab with the at least one guide slot causes the second body portion to translate axially into the receiving chamber of the end cap.

10. The pharmaceutical transport container of claim 9, wherein the at least one guide slot is helical.

11. The pharmaceutical transport container of claim 8, wherein the first body portion defines a hollow interior cavity to accept at least a cap end of the vial.

12. The pharmaceutical transport container of claim 11, wherein the first body portion comprises a radially-inward extending rim in the hollow interior cavity to engage a neck of the vial.

13. The pharmaceutical transport container of claim 8, wherein the second body portion comprises a retaining ring positioned in an interior cavity of the second body portion, the retaining ring maintaining the flexible ring in the interior cavity and abutting a radially-outward extending rim defined on an exterior surface of the first body portion.

14. The pharmaceutical transport container of claim 8, wherein the first body portion is formed as a clamshell movable from an open position to a closed position.

15. The pharmaceutical transport container of claim 8, wherein the first body portion and the second body portion are formed from a radiation-shielding material.

16. A pharmaceutical fluid injection system, comprising:

a pharmaceutical transport container, comprising;

a first body portion adapted to receive at least a portion of a pharmaceutical vial and defining an opening for establishing fluid communication with the vial, and comprising a proximal end;

a second body portion engageable with the first body portion to fully enclose the vial, the second body portion having a distal end engageable with the proximal end of the first body portion and a closed proximal end and defining an interior cavity therebetween;

a flexible ring positioned in the interior cavity of the second body portion and configured to flex between a relaxed state and a radially-outward extended state; and

a docking station to axially receive the pharmaceutical transport container therein, the docking station comprising a fluid connector element to establish fluid connection with the vial as the pharmaceutical transport container is received axially into the docking station,

wherein insertion of the first body portion into the interior cavity of the second body portion causes the flexible ring to deform from the relaxed state to the extended state thereby allowing the proximal end of the first body portion to be inserted therethrough, and after such insertion the flexible ring returns to the relaxed state to secure a removable engagement between the first body portion and the second body portion.

17. The pharmaceutical fluid injection system of claim 16, further comprising at least one guide tab extending radially from an exterior surface of the second body portion or within the docking station, the at least one guide tab configured to engage at least one guide slot defined in the exterior surface of the second body portion or defined within the receiving docking station, the at least one guide slot oriented such that engagement of the at least one guide tab with the at least one guide slot causes the second body portion to translate axially into the docking station to establish the fluid connection between the vial and a fluid connector element disposed within the docking station as a result of the axial translation.

18. The pharmaceutical fluid injection system of claim 17, wherein the docking station comprises a guide collar, wherein the at least one guide slot is defined in an interior surface of the guide collar.

19. The pharmaceutical fluid injection system of claim 17, wherein the at least one guide slot is helical.

20. The pharmaceutical fluid injection system of claim 16, wherein the fluid connector element comprises a vial spike to puncture a vial stopper at a cap end of the vial.

21. The pharmaceutical injection system of claim 16, wherein the first body portion comprises a radially-outward extending rim cooperating with the flexible ring.

22. The pharmaceutical fluid injection system of claim 21, wherein the radially-outward extending rim is configured to cause a radial deformation of the flexible ring when the first body portion is inserted into the second body portion.

23. The pharmaceutical fluid injection system of claim 21, wherein the radially-outward extending rim comprises an outer diameter greater than an inside distance across the flexible ring.

24. The pharmaceutical fluid injection system of claim 16, wherein the flexible ring is elliptically-shaped.

25. The pharmaceutical fluid injection system of claim 16, wherein the first body portion defines a proximally extending wall configured to receive and surround a body of the vial and being receivable within the interior cavity of the second body portion.