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Benzene sulfonamide thiazole and oxazole compounds

  • US 9,233,956 B2
  • Filed: 11/25/2013
  • Issued: 01/12/2016
  • Est. Priority Date: 05/06/2008
  • Status: Active Grant
First Claim
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1. A method for treating a susceptible neoplasm selected from melanoma and non-small cell lung cancer in a mammal in need thereof comprising the steps of:

  • (a) analyzing a sample from said neoplasm to determine whether an activating mutation is present in the coding sequence for B-Raf in cells of said neoplasm;

    (b) selecting a mammal having said neoplasm with an activating mutation in the coding sequence for B-Raf; and

    (c) administering a therapeutically effective amount the compound of formula

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