Benzene sulfonamide thiazole and oxazole compounds
First Claim
Patent Images
1. A method for treating a susceptible neoplasm selected from melanoma and non-small cell lung cancer in a mammal in need thereof comprising the steps of:
- (a) analyzing a sample from said neoplasm to determine whether an activating mutation is present in the coding sequence for B-Raf in cells of said neoplasm;
(b) selecting a mammal having said neoplasm with an activating mutation in the coding sequence for B-Raf; and
(c) administering a therapeutically effective amount the compound of formula
4 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
46 Citations
7 Claims
-
1. A method for treating a susceptible neoplasm selected from melanoma and non-small cell lung cancer in a mammal in need thereof comprising the steps of:
-
(a) analyzing a sample from said neoplasm to determine whether an activating mutation is present in the coding sequence for B-Raf in cells of said neoplasm; (b) selecting a mammal having said neoplasm with an activating mutation in the coding sequence for B-Raf; and (c) administering a therapeutically effective amount the compound of formula - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
Specification