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Topical composition comprising transformed bacteria expressing a compound of interest

  • US 9,234,204 B2
  • Filed: 08/07/2013
  • Issued: 01/12/2016
  • Est. Priority Date: 08/07/2012
  • Status: Expired due to Fees
First Claim
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1. A method of providing protection to human skin from UVA and UVB radiation, from 280-400 nm, by topically applying to the skin non-pathogenic, Gram-positive bacteria that has been genetically modified to express a mycosporine-like amino acid (MAA), wherein the method comprises the steps of(a) transforming non-pathogenic, Gram-positive bacteria selected from the group consisting of Lactobacillus lactis and Lactococcus lactis with a vector comprising a sequence encoding shinorine;

  • (b) expressing shinorine at a level of about 0.1 mM to about 100 mM for 102-1020 cfu of the transformed bacteria, and(c) topically applying to the skin of a human in need of protection from UVA and UVB radiation at least 102 cfu/cm2 of the transformed bacteria from step (a).

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