Analyte determination method and analyte meter
First Claim
1. A method for determining an analyte in a sample in which the sample is applied to an electrochemical test strip and evaluated using an analyte detection apparatus, wherein the sample may be a sample for evaluation or a control solution, wherein the analyte detection apparatus performs the steps of discriminating between a sample for evaluation and a control solution by the steps of:
- (a) applying a potential difference between first and second electrodes in the test strip for a period of time sufficient to establish a chemical potential gradient between the electrodes;
(b) thereafter switching off the applied potential whereby the chemical potential gradient begins to decay;
(c) determining the rate of decay of the chemical potential gradient in the absence of applied potential, and(d) comparing the determined rate of decay of the chemical potential gradient to pre-determined reference value, wherein the comparison indicates whether the applied sample is a sample for evaluation or a control solution.
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Accused Products
Abstract
The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
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Citations
16 Claims
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1. A method for determining an analyte in a sample in which the sample is applied to an electrochemical test strip and evaluated using an analyte detection apparatus, wherein the sample may be a sample for evaluation or a control solution, wherein the analyte detection apparatus performs the steps of discriminating between a sample for evaluation and a control solution by the steps of:
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(a) applying a potential difference between first and second electrodes in the test strip for a period of time sufficient to establish a chemical potential gradient between the electrodes; (b) thereafter switching off the applied potential whereby the chemical potential gradient begins to decay; (c) determining the rate of decay of the chemical potential gradient in the absence of applied potential, and (d) comparing the determined rate of decay of the chemical potential gradient to pre-determined reference value, wherein the comparison indicates whether the applied sample is a sample for evaluation or a control solution.
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2. A method for determining an analyte in a sample comprising the steps of:
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(a) applying the sample to an electrochemical test cell comprising a working and a counter electrode and a mediator that serves as a charge carrier in the electrochemical determination of the analyte, (b) electrochemically determining an uncorrected result for the determination of analyte in the applied sample; (c) determining a measure, tmob, of the mobility of the mediator in the applied sample, wherein the value of tmob, is indicative of the oxygen carrying capacity in the sample, and (d) modifying the uncorrected result of step (b) with a correction factor based on the determined value of tmob to provide a corrected determination of analyte in the sample. - View Dependent Claims (3, 4, 5, 6)
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7. A meter for receiving an electrochemical test strip having electrodes and providing a determination of an analyte in a sample applied to the electrochemical test strip when received in the meter, said meter comprising
(a) a housing having a slot for receiving an electrochemical test strip; -
(b) communications means for receiving input from and communicating a result to a user; and (c) means for determining an uncorrected result for the determination of analyte in the sample, a measure, tmob, of the mobility of the mediator in the applied sample, wherein the value of tmob is indicative of the oxygen carrying capacity in the sample, and modifying the uncorrected result of step (b) with a correction factor based on the determined value of tmob to provide a corrected determination of analyte in the sample. - View Dependent Claims (8, 9, 10, 11)
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12. A measurement system comprising:
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a meter for receiving an electrochemical test strip having electrodes and providing a determination of an analyte in a sample applied to the electrochemical test strip when received in the meter, said meter comprising (a) a housing having a slot for receiving an electrochemical test strip; (b) communications means for receiving input from and communicating a result to a user; and (c) means for determining an uncorrected result for the determination of analyte in the sample, a measure, tmob, of the mobility of the mediator in the applied sample, wherein the value of tmob is indicative of the oxygen carrying capacity in the sample, and modifying the uncorrected result of step (b) with a correction factor based on the determined value of tmob to provide a corrected determination of analyte in the sample; and an electrochemical test strip disposed within the housing. - View Dependent Claims (13, 14, 15, 16)
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Specification