Method and system for patient-specific modeling of blood flow

• US 9,235,679 B2
• Filed: 03/21/2014
• Issued: 01/12/2016
• Est. Priority Date: 08/12/2010
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: Taylor, Charles A.
• Primary Examiner(s): Clow, Lori A
• Application Number:
  US14/222,424
• Publication Number:
  US 20140236492A1
• Time in Patent Office: 662 Days
• Field of Search: None
• US Class Current: 1/1
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Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.

Claims

1. A system for determining cardiovascular information for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries, and the patient-specific data including image data;

create a three-dimensional model representing at least a portion of the anatomical structure of the patient using the patient-specific data;

determine a myocardial mass of the patient using the patient-specific data;

estimate total coronary blood flow of the patient using the determined myocardial mass;

create a reduced-order blood flow model relating to a blood flow characteristic within the portion of the anatomical structure based, at least in part, on the estimated total coronary blood flow and the three-dimensional model;

create a multi-dimensional model using the three-dimensional model and the reduced-order blood flow model; and

determine a value of a fractional flow reserve at each of a plurality of locations within the portion of the anatomical structure using the multi-dimensional model.

2. The system of claim 1, wherein the total coronary blood flow is one of a hyperemic total coronary blood flow and a resting total coronary blood flow.

3. The system of claim 1, wherein the computer system is configured to create the three-dimensional model by performing steps to:

determine centerlines of the one or more coronary arteries; and

divide the one or more coronary arteries into one or more segments using the determined centerlines.

4. The system of claim 1, wherein the reduced-order blood flow model comprises one or more boundary conditions representing fluid flow through at least one inlet or at least one outlet of the three-dimensional model.

5. The system of claim 1, wherein the reduced-order blood flow model comprises a one-dimensional model of a first portion of the anatomical structure and a lumped parameter model of a second portion of the anatomical structure.

6. The system of claim 1, wherein the reduced-order blood flow model comprises a one-dimensional model used to simulate blood flow in one or more coronary arteries.

7. The system of claim 1, wherein the reduced-order blood flow model comprises a lumped parameter model used to simulate coronary microcirculation.

8. The system of claim 1, wherein:

the fractional flow reserve indicates a ratio between a blood flow or pressure at a first location in the one or more coronary arteries and a blood flow or pressure at a second location upstream from the first location; and

the at least one computer system is configured to determine the fractional flow reserve at a plurality of locations in the one or more coronary arteries.

9. The system of claim 1, wherein the computer system is further configured to:

determine blood flow of the one or more coronary arteries while modeling a hyperemic state of the patient using the reduced-order blood flow model.

10. The system of claim 1, wherein the fractional flow reserve is calculated using a resting blood flow of the patient.

17. The method of claim 1, wherein the reduced-order blood flow model comprises a lumped-parameter model used to simulate coronary microcirculation.

18. The method of claim 1, wherein:

the fractional flow reserve indicates a ratio between a blood flow or pressure at a first location in the one or more coronary arteries and a blood flow or pressure at a second location upstream from the first location; and

the at least one computer system is configured to determine the fractional flow reserve at a plurality of locations in the one or more coronary arteries.

19. The method of claim 1, further comprising:

determining blood flow of the one or more coronary arteries while modeling a hyperemic state of the patient using the reduced-order blood flow model.

20. The method of claim 1, wherein the fractional flow reserve is calculated using a resting blood flow of the patient.

11. A computer-implemented method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:

receiving patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries, and the patient-specific data including image data;

creating a three-dimensional model representing at least a portion of the anatomical structure of the patient using the patient-specific data;

determining a myocardial mass of the patient using the patient-specific data;

estimating, using at least one computer processor, total coronary blood flow of the patient using the determined myocardial mass;

creating a reduced-order blood flow model relating to a blood flow characteristic within the portion of the anatomical structure based, at least in part, on the estimated total coronary blood flow and the three-dimensional model;

creating a multi-dimensional model using the three-dimensional model and the reduced-order blood flow model; and

determining, using at least one computer processor, a value of a fractional flow reserve at each of a plurality of locations within the portion of the anatomical structure using the multi-dimensional model.

12. The method of claim 11, wherein the total coronary blood flow is one of a hyperemic total coronary blood flow and a resting total coronary blood flow.

13. The method of claim 11, wherein creating the three-dimensional model comprises:

determining centerlines of the one or more coronary arteries; and

dividing the one or more coronary arteries into one or more segments using the determined centerlines.

14. The method of claim 11, wherein the reduced-order blood flow model comprises one or more boundary conditions representing fluid flow through at least one inlet or at least one outlet of the three-dimensional model.

15. The method of claim 11, wherein the reduced-order blood flow model comprises a one-dimensional model of a first portion of the anatomical structure and a lumped-parameter model of a second portion of the anatomical structure.

16. The method of claim 11, wherein the reduced-order blood flow model comprises a one-dimensional model used to simulate blood flow in one or more coronary arteries.

21. A system for determining cardiovascular information for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries, and the patient-specific data including image data;

create a first model, in three dimensions, representing a portion of the anatomical structure of the patient using the patient-specific data;

determine a myocardial mass or total coronary blood flow of the patient using the patient-specific data;

create a second model comprising a reduced-order model, using one or more fluid dynamics equations, relating to fluid flow within the portion of the anatomical structure using, at least in part, the determined myocardial mass or total coronary blood flow;

create a multi-dimensional model using the first model and the second model;

determine a value of a blood flow characteristic at each of a plurality of locations of the portion of the anatomical structure using the multi-dimensional model.

22. The system of claim 21, wherein the blood flow characteristic comprises a fractional flow reserve.

23. The system of claim 21, wherein the computer system is configured to create the first model in three dimensions using steps to:

determine centerlines of the one or more coronary arteries; and

divide the one or more coronary arteries into one or more segments using the determined centerlines.

24. The system of claim 21, wherein the second model includes a one-dimensional model of blood flow through one or more coronary arteries and a lumped-parameter model of blood flow upstream and/or downstream of the one or more coronary arteries modeled by the one-dimensional model.

25. The system of claim 21, wherein the second model includes a reduced-order model of blood flow through one or more coronary arteries and a lumped-parameter model of blood flow upstream and/or downstream of the one or more coronary arteries modeled by the reduced-order model.

26. A system for determining cardiovascular information for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries, and the patient-specific data including image data;

create a three-dimensional model representing at least a portion of one or more coronary arteries using the received patient-specific data, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet;

create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, wherein the at least one boundary condition model has fewer than three dimensions;

create a multi-dimensional model using the three-dimensional model and the boundary condition model; and

determine a value of a fractional flow reserve at each of a plurality of locations of the one or more coronary arteries using the multi-dimensional model.

27. The system of claim 26, wherein the at least one boundary condition model comprises a lumped-parameter model of one or more coronary arteries.

28. The system of claim 26, wherein the at least one boundary condition model comprises a lumped-parameter model of one or more locations upstream or downstream from one or more coronary arteries.

29. The system of claim 26, wherein:

the fractional flow reserve indicates a ratio between a blood flow or pressure at a first location in the one or more coronary arteries and a blood flow or pressure at a second location upstream from the first location; and

the at least one computer system is configured to determine the fractional flow reserve at a plurality of locations in the one or more coronary arteries.

30. The system of claim 26, wherein the computer system is further configured to:

determine a blood flow, pressure, or fractional flow reserve from a location of the one or more coronary arteries while modeling a hyperemic state of the patient using the boundary condition model.