System and method for noninvasively monitoring conditions of a subject

• US 9,237,850 B2
• Filed: 02/22/2012
• Issued: 01/19/2016
• Est. Priority Date: 06/04/2007
• Status: Active Grant

• Current Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Original Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Inventors: Metzger, Yaacov, Rokni, Michal, Pery-Shechter, Revital
• Primary Examiner(s): Luong, Peter
• Application Number:
  US13/402,275
• Publication Number:
  US 20120150014A1
• Time in Patent Office: 1,427 Days
• Field of Search: 600/407, 600/437, 600/439, 600/473, 600/476
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0097 by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 2021/1727 Magnetomodulation
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method and system are presented for use in determining one or more parameters of a subject. A region of interest of the subject is irradiated with acoustic tagging radiation, which comprises at least one acoustic tagging beam. At least a portion of the region of interest is irradiated with at least one electromagnetic beam of a predetermined frequency range. Electromagnetic radiation response of the at least portion of the region of interest is detected and measured data indicative thereof is generated. The detected response comprises electromagnetic radiation tagged by the acoustic radiation. This enables processing of the measured data indicative of the detected electromagnetic radiation response to determine at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and outputting data indicative of the at least one determined parameter.

Claims

1. A probe device for use in noninvasive monitoring of at least one parameter of a region of interest in a subject'"'"'s body, the probe device comprising a support structure and a control unit wherein:

said support structure configured to be put in contact with the body part, the support structure comprising;

at least one acoustic output port associated with an acoustic unit and

an arrangement of light ports comprising light input and output ports associated with respectively a detection assembly and an illumination assembly, said arrangement of light ports comprising at least one light output port located within an aperture of the acoustic unit, and a plurality of the light input ports located around said at least one light output port, wherein location of said light output and input ports is interchangeable, said arrangement of the light ports thereby defining pairs of the light output and input ports characterized by different source-detector distances r_sd and enabling illumination and detection of light using at least one selected operative pair of the light input and output ports to illuminate a region in the subject'"'"'s body by illuminating light coming from at least one light output port, irradiate a region in the body with acoustic radiation coming from the at least one acoustic output port, and collect light scattered from the illuminated region in the body by at least one light input port;

wherein when the probe device is operated, overlapping between the illuminating light and the acoustic radiation induces tagging of light scattered from an overlapping region by the acoustic radiation;

wherein said control unit is connected to said arrangement of light ports and the at least one acoustic output port, and is preprogrammed to manage a measurement session by selecting the at least one operative pair of the operative light input and output ports with respect to the at least one acoustic output port to provide an operating condition of the probe during the measurement session, the operating condition corresponding to at least one selected value of the source detector distance r_sd is sufficiently small such that a difference in optical paths of shallow photons and deep photons in the illuminating light defining an optical attenuation coefficient depends on a distance traveled in a direction z and not on differences in optical paths in x or y dimensions, and light collected by said at least one operative light input port comprises the scattered light originated in the overlapping region, thereby enabling improved-accuracy calculation of the optical attenuation coefficient from light collected by the operative light input port and determination of at least one parameter of the region of interest, wherein z is a direction parallel to a direction of propagation of the acoustic radiation towards the region of interest.

2. A probe of claim 1, comprising an electronic filter, connected to the at least one light input port and configured and operable for receiving the collected light and filtering low frequency signals therein to thereby extract signals corresponding to the scattered tagged light.

3. A probe of claim 1, wherein the control unit comprises an electronic filter, connected to the at least one light input port and configured and operable for receiving the collected light and filtering low frequency signals therein to thereby extract signals corresponding to the scattered tagged light.

4. A probe device of claim 1, wherein the control unit comprises:

a data processing and analyzing utility configured and operable for receiving and analyzing data indicative of the collected light and generating output data indicative of at least one parameter of the subject, and a data presentation utility responsive to the output data of the processing and analyzing utility for presenting said at least parameter to user.

5. A probe device of claim 1, wherein said at least one parameter comprises at least one of the following:

blood flow;

oxygen saturation; and

hemoglobin concentration.

6. A probe device of claim 1, wherein the control unit is configured and operable for determining multiple parameters of the subject, the control unit comprises a display configured to display the multiple parameters sequentially or concurrently to a user.

7. A probe device of claim 1, wherein said arrangement on the support structure comprises a single acoustic port.

8. A probe device of claim 1, wherein said arrangement on the support structure comprises a plurality of the acoustic ports arranged in a spaced apart relationship on the support structure.

9. A probe device of claim 1, wherein said arrangement on the support structure comprises a plurality of the light output ports at different locations along the support structure.

10. A probe device of claim 1, wherein said arrangement on the support structure comprises a plurality of the light input ports at different locations along the support structure.

11. A probe device of claim 1, wherein the at least one light input port and the at least light output port accommodated within said aperture.

12. A probe device of claim 1, wherein the at least one light input port is located within said aperture of the acoustic unit, and multiple light output ports are arranged in an essentially circular array outside the acoustic unit around said at least one light input port.

13. A probe device of claim 1, wherein the at least one light output port is located within said aperture of the acoustic unit, and multiple light input ports are arranged in an essentially circular array outside the acoustic unit around said at least one light output port.

14. A system for use in determining one or more parameters of a subject, the system comprising:

the probe device of claim 1; and

an external control system which comprises the illumination assembly, the detection assembly, and the acoustic unit, and which is connected to said control unit of the probe device.

15. A system of claim 14, wherein the acoustic unit comprises a signal generator and an acoustic transducer arrangement, said signal generator being configured and operable to generate the acoustic waves comprising at least one coded acoustic wave in the form of a predetermined function of at least one parameter of the acoustic radiation varying over time during a predetermined time interval used for measurements.

16. A system of claim 15, wherein said coded acoustic wave is a continuous wave and said predetermined function has a narrow autocorrelation.