Diagnosis of asthma

• US 9,237,862 B2
• Filed: 03/04/2010
• Issued: 01/19/2016
• Est. Priority Date: 03/10/2009
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Bussa, Nagaraju, Jain, Abhishek, Rajamani, Kumar Thirunellai
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): WEARE, MEREDITH H
• Application Number:
  US13/203,838
• Publication Number:
  US 20120089042A1
• Time in Patent Office: 2,147 Days
• Field of Search: 600529-534
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0261 Strain gauges
• CPC Class Codes: A61B 5/113 occurring during breathing
• CPC Class Codes: A61B 5/6819 Nose
• CPC Class Codes: A61B 5/6822 Neck
• CPC Class Codes: A61B 5/6833 Adhesive patches

Abstract

An apparatus (200) for diagnosing asthma is disclosed. The apparatus (200) comprises a data acquisition module (210) configured to acquire at least one physical deformation feature associated with at least one of nasal flaring, neck retraction and inter-coastal retraction of a subject under examination and an analysis module (220) configured to analyze the acquired at least one physical deformation feature associated with at least one of the nasal flaring, the neck retraction and the inter-coastal retraction of the subject under examination and diagnose the asthma based on the analyzed at least one physical deformation feature associated with at least one of the nasal flaring, the neck retraction and the inter-coastal retraction of the subject under examination. The disclosed apparatus (200) can be used for monitoring asthma at home, at hospital or in ambulatory patients.

Claims

1. An apparatus for diagnosing asthma, the apparatus comprising;

a data acquisition module configured to acquire measurements of nasal flaring and neck refraction of a subject under examination wherein the data acquisition module comprises

a first strain gauge adapted to be placed on a nostril of the subject and configured to acquire measurements of nasal flaring of the subject during at least one respiratory cycle; and

a second strain gauge adapted to be placed on a neck of the subject and configured to acquire measurements of neck retraction of the subject under examination during at least one respiratory cycle;

wherein the physical deformation features are measured in a form of electrical variation associated with nasal flaring and neck retraction of the subject under examination; and

an analysis module configured to analyze the acquired measurements of nasal flaring and neck retraction of the subject under examination and diagnose the asthma based on the analyzed measurements of nasal flaring and neck retraction of the subject under examination.

2. The apparatus as claimed in claim 1, wherein the at least one strain gauge is a mercury-in-rubber strain gauge.

3. The apparatus as claimed in claim 2, wherein the analysis module further comprises

a recording module configured to digitally record for a pre-determined time period the acquired at least one physical deformation feature in the form of electrical variation associated with nasal flaring, neck retraction and intercostal refraction of the subject under examination;

a feature extraction module configured to extract time domain feature and/or frequency domain feature from the digitally recorded at least one physical deformation feature in the form of electrical variation associated with the nasal flaring, the neck retraction and the intercostal retraction of the subject under examination; and

a storing module configured to store the extracted time domain feature and/or frequency domain feature electrical variation associated with the nasal flaring, the neck retraction and the intercostal retraction of the subject under examination.

4. The apparatus as claimed in claim 3, wherein the feature extraction module is configured to extract at least one of

a) respiratory cycles associated with the nasal flaring, the neck retraction and the intercostal retraction

b) an average of the electrical variations over a pre-determined number of respiratory cycles associated with the nasal flaring, the neck retraction and the intercostal retraction

c) frequency bands present in the respiratory cycles associated with nasal flaring, the neck retraction and the intercostal retraction

d) a minimum frequency band and a maximum frequency band present in the respiratory cycles associated with the nasal flaring, the neck retraction and the intercostal retraction.

5. The apparatus as claimed in claim 3, wherein the analysis module further comprises

an input module configured to receive input, the input being at least one of gender, age, height, weight and ethnicity of the subject under examination;

and

a pre-classified calibrated database having physical deformation data associated with non-asthmatic subjects and asthmatic subjects, the physical deformation data including time domain and/or frequency domain features and at least one additional feature of

a) gender

b) age

c) height

d) weight

e) ethnicity

f) wherein the time domain and/or frequency domain features are extracted using the acquired physical deformations in the form of electrical variation associated with the nasal flaring, the neck refraction and the intercostal retraction

g) condition of the subject;

non-asthmatic, onset of asthma, mild asthma, acute asthma.

6. The apparatus as claimed in claim 5, wherein the analysis module further comprises a logic module configured to compare physical deformations of the extracted time domain and/or frequency domain associated with the nasal flaring, the neck retraction and the intercostal retraction of the subject under examination with the data available in the pre-classified calibrated database and diagnose the asthma condition of the subject under examination and store the diagnosis related information.

7. The apparatus as claimed in claim 1, further comprising a notification module, the notification module being at least one of a visual display unit, an audio unit or a colored light generation unit, the notification module configured to notify when one or more of the following conditions are met:

i) whether the nasal flaring, the neck retraction and an intercostal retraction is detected ii) the need for emergency consultation if the diagnosed asthma is above a pre-determined threshold iii) that there is no need for emergency consultation if the diagnosed asthma is below a pre-determined threshold.

8. The apparatus as claimed in claim 1, further comprising an evaluation module configured to evaluate the progress of therapy or remission based on the evaluation of one or more of the following features:

i) the acquired measurements of nasal flaring and neck retraction and/or an inter-coastal refraction of the subject under examination ii) a previously stored physical deformation feature associated with the nasal flaring, the neck retraction and/or the intercostal retraction of the subject under examination.

9. The apparatus as claimed in claim 1, further comprising a wheeze monitoring device, wherein the analysis module diagnoses the asthma based on an output from the wheeze monitoring device.

10. A method for diagnosing asthma, the method being implemented in a computer system including one or more physical processors storage media storing machine-readable instructions, and two or more strain gauges, the method comprising

acquiring data from physical deformation features associated with nasal flaring and neck retraction of a subject, wherein the acquiring data comprises;

placing a first strain gauge on a nostril of the subject, wherein the first strain gauge is configured to acquire measurements of nasal flaring of the subject during at least one respiratory cycle; and

placing a second strain gauge on a neck of the subject, wherein the second strain gauge is configured to acquire measurements of neck retraction of the subject during at least one respiratory cycle;

wherein the physical deformation features are measured in a form of electrical variation associated with nasal flaring and neck retraction of the subject under examination;

analyzing the acquired data for physical deformation features associated with each of the nasal flaring and the neck retraction; and

comparing the acquired data with stored diagnostic data patterns indicative of diagnosing asthma based on the analyzed physical deformation features associated with nasal flaring and neck retraction.