Bioerodible wraps and uses therefor
First Claim
1. A tubular tissue graft device comprising:
- a living tubular tissue structure having a wall surrounding a lumen, the wall having an outer surface comprising a series of non-circular cross-sections varying at least in part over a portion of the length of the living tubular tissue structure; and
an electrospun deposition coating formed of one or more bioerodible polymer fibers oriented circumferentially about the outer surface and along a portion of the length of the living tubular tissue structure, wherein the coating forms a restrictive fiber matrix with inherent anisotropy on the series of non-circular cross-sections that compose the outer surface of the living tubular tissue structure.
2 Assignments
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Accused Products
Abstract
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
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Citations
83 Claims
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1. A tubular tissue graft device comprising:
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a living tubular tissue structure having a wall surrounding a lumen, the wall having an outer surface comprising a series of non-circular cross-sections varying at least in part over a portion of the length of the living tubular tissue structure; and an electrospun deposition coating formed of one or more bioerodible polymer fibers oriented circumferentially about the outer surface and along a portion of the length of the living tubular tissue structure, wherein the coating forms a restrictive fiber matrix with inherent anisotropy on the series of non-circular cross-sections that compose the outer surface of the living tubular tissue structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A method of preparing a tubular tissue graft device, the method comprising:
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providing a living tubular tissue structure having a wall surrounding a lumen, the wall having an outer surface comprising a series of non-circular cross-sections varying at least in part over a portion of the length of the living tubular tissue structure; and electrospinning a deposition coating formed of one or more bioerodible polymer fibers oriented circumferentially about the outer surface and along a portion of the length of the living tubular tissue structure, wherein the coating forms a restrictive fiber matrix with inherent anisotropy on the series of non-circular cross-sections that compose the outer surface of the living tubular tissue structure. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
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77. A tubular tissue graft device comprising:
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a living tubular tissue structure having a wall surrounding a lumen, the wall having an outer surface comprising a series of non-circular cross-sections varying at least in part over a portion of the length of the living tubular tissue structure; and an electrospun deposition coating formed of bioerodible polymer fibers oriented circumferentially about the outer surface and along a portion of the length of the living tubular tissue structure, wherein the coating forms a restrictive fiber matrix with inherent anisotropy on the series of non-circular cross-sections that compose the outer surface of the living tubular tissue structure such that the fiber matrix limits the living tubular tissue structure from expanding beyond a predetermined maximum distension size for the living tubular tissue structure.
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78. A method of preparing a tubular tissue graft device, the method comprising:
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providing a living tubular tissue structure having a wall surrounding a lumen, the wall having an outer surface comprising a series of non-circular cross-sections varying at least in part over a portion of the length of the living tubular tissue structure; and electrospinning a deposition coating formed of one or more bioerodible polymer fibers oriented circumferentially about the outer surface and along a portion of the length of the living tubular tissue structure by applying a potential difference between a deposition nozzle and a target where the target has a negative electrical potential relative to ground, wherein the coating forms a restrictive fiber matrix with inherent anisotropy on the series of non-circular cross-sections that compose the outer surface of the living tubular tissue structure. - View Dependent Claims (79, 80, 81, 82, 83)
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Specification