Tissue-based compositions
First Claim
Patent Images
1. A composition comprising:
- spleen extracellular matrix in sheet form, the spleen extracellular matrix retaining native growth factors of spleen tissue, and retaining a native structure of the spleen tissue, such that the spleen extracellular matrix includes a reticular matrix structure derived from a reticular component of the spleen tissue; and
a second extracellular matrix, other than spleen extracellular matrix, the second extracellular matrix being integrated into the reticular matrix structure of the spleen extracellular matrix;
wherein the composition is configured for administration to a patient.
1 Assignment
0 Petitions
Accused Products
Abstract
Compositions comprising extracellular matrix (ECM) materials and methods of use thereof are disclosed. The compositions may comprise two or more ECM materials derived from different types of tissues, such as, e.g., lung tissue and spleen tissue, formulated for administration to a patient or configured as a medical device for implantation in or application to the patient. The compositions may combine complementary properties of different types of ECM materials for customized patient-specific and/or site-specific tissue repair and/or regeneration.
-
Citations
30 Claims
-
1. A composition comprising:
-
spleen extracellular matrix in sheet form, the spleen extracellular matrix retaining native growth factors of spleen tissue, and retaining a native structure of the spleen tissue, such that the spleen extracellular matrix includes a reticular matrix structure derived from a reticular component of the spleen tissue; and a second extracellular matrix, other than spleen extracellular matrix, the second extracellular matrix being integrated into the reticular matrix structure of the spleen extracellular matrix; wherein the composition is configured for administration to a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 29)
-
-
14. A composition comprising:
-
spleen extracellular matrix in sheet form, the spleen extracellular matrix retaining native growth factors of spleen tissue, and retaining a native structure of the spleen tissue, such that the spleen extracellular matrix includes a reticular matrix structure derived from a reticular component of the spleen tissue; and a second extracellular matrix comprising at least one mammalian extracellular matrix chosen from lung extracellular matrix, gall bladder extracellular matrix, bone marrow extracellular matrix, pancreatic extracellular matrix, or liver extracellular matrix, the second extracellular matrix being integrated into the spleen extracellular matrix; wherein the spleen extracellular matrix has a higher native growth factor content than the second extracellular matrix, and the second extracellular matrix is integrated into the reticular matrix structure of the spleen extracellular matrix; wherein the spleen extracellular matrix is in a form different from a form of the second extracellular matrix; and wherein the composition is configured for application to native tissue of a patient for repairing the native tissue. - View Dependent Claims (15, 16, 17, 18)
-
-
19. A composition comprising:
-
spleen extracellular matrix in sheet form, the spleen extracellular matrix retaining native growth factors of spleen tissue, and retaining a native structure of the spleen tissue, such that the spleen extracellular matrix includes a reticular matrix structure derived from a reticular component of the spleen tissue; and lung extracellular matrix; wherein the composition includes at least two layers, at least one of the layers comprising the lung extracellular matrix integrated into the reticular matrix structure of the spleen extracellular matrix; and wherein the composition is configured for application to native tissue of a patient for repairing the native tissue. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
-
-
27. A composition comprising:
-
spleen extracellular matrix in sheet form, the spleen extracellular matrix retaining native growth factors of spleen tissue, and retaining a native structure of the spleen tissue, such that the spleen extracellular matrix includes a reticular matrix structure derived from a reticular component of the spleen tissue coupled to a layer portion derived from an outer membrane of the spleen tissue; and lung extracellular matrix in particulate form, gel form, or liquid form and is integrated into the spleen extracellular matrix; wherein the composition is configured for application to native tissue of a patient for repairing the native tissue. - View Dependent Claims (28, 30)
-
Specification