Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
First Claim
1. A device comprising:
- one or more implantable cooling elements configured to be applied to one or more tissues of a vertebrate subject,wherein each of the one or more implantable cooling elements includes a first portion configured to be in association with one or more first tissues to be cooled, and a second portion including two or more branches configured to be placed in association with one or more second tissues adjacent to an external epidermal tissue of the vertebrate subject; and
at least one programmable controller operably configured to provide instructions to the one or more implantable cooling elements in response to information regarding a plasma level of one or more of a metabolic analyte, a sugar, a lipoprotein, or a fatty acid in the vertebrate subject.
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Accused Products
Abstract
Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.
118 Citations
43 Claims
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1. A device comprising:
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one or more implantable cooling elements configured to be applied to one or more tissues of a vertebrate subject, wherein each of the one or more implantable cooling elements includes a first portion configured to be in association with one or more first tissues to be cooled, and a second portion including two or more branches configured to be placed in association with one or more second tissues adjacent to an external epidermal tissue of the vertebrate subject; and at least one programmable controller operably configured to provide instructions to the one or more implantable cooling elements in response to information regarding a plasma level of one or more of a metabolic analyte, a sugar, a lipoprotein, or a fatty acid in the vertebrate subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A system comprising:
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a non-transitory signal-bearing medium configured for use in a computing device including, one or more instructions for receiving data including data for applying cooling to one or more first tissues of a vertebrate subject with one or more implantable cooling elements, wherein the one or more implantable cooling elements are configured to lower the temperature of the one or more first tissues and thereby modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein each of the one or more implantable cooling elements includes a first portion configured to be in association with the one or more first tissues to be cooled, and a second portion including two or more branches configured to be placed in association with one or more second tissues adjacent to an external epidermal tissue of the vertebrate subject; and one or more instructions for controlling the one or more implantable cooling elements with at least one programmable controller operably configured to provide instructions to the one or more implantable cooling elements in response to information regarding a plasma level of one or more of a metabolic analyte, a sugar, a lipoprotein, or a fatty acid in the vertebrate subject. - View Dependent Claims (42, 43)
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Specification