Method and apparatus for improving ion transmission into a mass spectrometer

• US 9,240,310 B2
• Filed: 04/28/2015
• Issued: 01/19/2016
• Est. Priority Date: 02/01/2013
• Status: Active Grant

• Current Assignee: Rockefeller University
• Original Assignee: Rockefeller University
• Inventors: Krutchinsky, Andrew N., Padovan, Julio, Cohen, Herbert, Chait, Brian T.
• Primary Examiner(s): SMYTH, ANDREW P
• Application Number:
  US14/698,364
• Publication Number:
  US 20150318155A1
• Time in Patent Office: 266 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: H01J 49/0031 Step by step routines describing the use of the apparatus H01J49/0081 takes precedence
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421
• CPC Class Codes: H01J 49/4225 Multipole linear ion traps, e.g. quadrupoles, hexapoles

Abstract

An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum. The vacuum chamber can be a chamber of a vacuum housing enclosing a mass analyzer.

Claims

1. A method for transferring ions from atmosphere to a vacuum chamber of a mass spectra analysis system, the method comprising:

receiving ions from an ion source at atmosphere at an entrance aperture of a diverging duct electrode disposed proximate to the ion source;

conveying the ions through a tube of the diverging duct electrode toward an exit aperture of the diverging duct electrode, the tube having a continuous inner surface defining an enclosed diverging channel between the entrance aperture and the exit aperture, and the exit aperture having an inner diameter larger than an inner diameter of the entrance aperture, the diverging channel narrowing the beam of ions; and

injecting the ions from the exit aperture of the diverging duct electrode into the a vacuum chamber of a mass spectra analysis system, the exit aperture being operatively coupled to the vacuum chamber for transferring the ions thereto; and

wherein the diverging channel has an angle of divergence greater than 0.5 degrees and less than about 5 degrees.

2. A method as defined in claim 1, wherein the diverging channel has an angle of divergence greater than 0.5 degrees and less than about 5 degrees and a length from about 1 mm to about 200 mm to narrow a beam comprising the ions formed at the entrance aperture and to transport the ions in the narrowed beam to the vacuum chamber.

3. A method as defined in claim 1, wherein the ion source is a nano-flow electrospray ion source.

4. A method as defined in claim 1, further comprising applying a voltage of about 500V to about 5 kV on the ion source.

5. A method as defined in claim 1, further comprising applying a voltage on the diverging duct electrode with a voltage source.

6. A method as defined in claim 1, further comprising heating the ions in the diverging duct electrode to cause desolvation.

7. A method as defined in claim 6, wherein the ions are heated by a heating source providing radiative heat.

8. A method as defined in claim 1, further comprising analyzing the injected ions with a quadrupole mass analyzer.

9. A method as defined in claim 1, wherein the entrance aperture of the diverging duct electrode is positioned a distance of between about 0.1 mm and about 10 mm from an exit port of the ion source.

10. A method as defined in claim 1, wherein an inner diameter of the entrance aperture of the diverging duct electrode is from about 0.1 mm to about 1 mm.

11. A system for mass spectra analysis of ions, the system comprising:

an electrospray ion source for spraying a divergent beam of ions produced by charging droplets of a solution of molecules introduced into the electrospray source, the electrospray ion source comprising an exit port from which the ions are electrosprayed at atmosphere;

a mass analyzer having an inlet port enclosed in a vacuum housing for receiving the ions formed in the electrospray ion source to be analyzed; and

an ion transmission interface for transferring the ions from the electrospray ion source to the vacuum housing, the ion transmission interface comprising;

a diverging duct electrode comprising a tube having a continuous inner surface defining an entrance aperture and an exit aperture and an enclosed diverging channel therebetween, the exit aperture having an inner diameter larger than an inner diameter of the entrance aperture, the entrance aperture positioned proximate the exit port of the electrospray ion source and receiving the ions at atmosphere from the electrospray ion source, the diverging channel narrowing the beam of ions; and

an electrode holder coupled between the exit aperture of the diverging duct electrode and the vacuum housing for transporting the ions to the mass analyzer under vacuum; and

wherein the diverging channel has an angle of divergence greater than 0.5 degrees and less than about 5 degrees.

12. A system as defined in claim 11, wherein the diverging channel has an angle of divergence greater than 0.5 degrees and less than about 5 degrees and a length from about 1 mm to about 200 mm.

13. A system as defined in claim 11, wherein the electrospray ion source is a nano-flow electrospray ion source.

14. A system as defined in claim 11, further comprising a voltage source for applying a voltage of about 500V to about 5 kV on the ion source.

15. A system as defined in claim 11, wherein the ion transmission interface comprises a voltage source for applying a voltage on the diverging duct electrode with a voltage source.

16. A system as defined in claim 11, wherein the ion transmission interface comprises a heating source for heating the ions in the diverging duct electrode to cause desolvation.

17. A system as defined in claim 16, wherein the ions are heated by a heating source providing radiative heat.

18. A system as defined in claim 11, wherein the mass analyzer is a quadrupole mass analyzer.

19. A system as defined in claim 11, wherein the vacuum housing encloses a first vacuum chamber and a second vacuum chamber, the first vacuum chamber enclosing the exit aperture of the diverging duct electrode, the system further comprising a skimmer, the second vacuum chamber enclosing an outlet side of the skimmer and the inlet port of the mass analyzer, and wherein the second vacuum chamber is maintained at a greater vacuum than that of the first vacuum chamber.

20. A system as defined in claim 11, wherein the entrance aperture of the diverging duct electrode is positioned a distance of between about 0.1 mm and about 10 mm from the exit port of the electrospray ion source.