Methods and systems for conditioning physiological information using a normalization technique

• US 9,241,670 B2
• Filed: 09/11/2012
• Issued: 01/26/2016
• Est. Priority Date: 09/11/2012
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Rodriguez-Llorente, Fernando, Engelbrecht, Pirow, Wooder, Nicholas James
• Primary Examiner(s): Fernandez, Katherine
• Assistant Examiner(s): Negarestan, Farshad
• Application Number:
  US13/609,414
• Publication Number:
  US 20140073935A1
• Time in Patent Office: 1,232 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

A physiological monitoring system may determine physiological information, such as physiological rate information, from a physiological signal. The system may condition the physiological signal to assist in the determination of the physiological information. The system may generate a positive signal and a negative signal based on respective positive and negative values of the physiological signal. The system may filter the positive and negative signals, combine the filtered signals, and modify the physiological signal based on the combined signal. The physiological signal may be modified, for example, by subtracting the combined signal from the physiological signal.

Claims

1. A subject pulse oximetry monitoring system for conditioning determining a physiological rate, comprising:

a pulse oximetry sensor configured to generate a physiological signal, wherein the pulse oximetry sensor is configured to detect light attenuated by a subject; and

a pulse oximeter coupled to the pulse oximetry sensor, wherein equipment pulse oximeter is configured to;

receive the physiological signal from the pulse oximetry sensor;

generate a positive signal by replacing each negative value of the physiological signal with a predetermined value;

generate a negative signal by replacing each positive value of the physiological signal with a predetermined value;

filter the positive signal to generate a filtered positive signal;

filter the negative signal to generate a filtered negative signal;

combine the filtered positive signal and the filtered negative signal to generate a combined signal;

modify the physiological signal based on the combined signal;

determine a physiological rate of the subject based on the modified physiological signal; and

display the physiological rate of the subject on a display.

2. The system of claim 1, wherein the pulse oximeter is further configured to:

generate the positive signal by replacing each negative value of the physiological signal with a zero; and

generate the negative signal by replacing each positive value of the physiological signal with a zero.

3. The system of claim 1, wherein the pulse oximeter is further configured to:

low pass filter the positive signal; and

low pass filter the negative signal.

4. The system of claim 1, wherein the pulse oximeter is further configured to average the filtered positive signal and the filtered negative signal.

5. The system of claim 1, wherein the pulse oximeter is further configured to scale the combined signal prior to modification of the physiological signal based on the combined signal.

6. The system of claim 5, wherein the pulse oximeter is further configured to scale the combined signal based on a standard deviation of the combined signal.

7. The system of claim 1, wherein the pulse oximeter is further configured to modify the physiological signal by subtracting the combined signal from the physiological signal.

8. A processing module of a pulse oximeter for determining a physiological rate, wherein the processing module is configured to:

receive a physiological signal derived from a pulse oximetry sensor, wherein the pulse oximetry sensor is configured to detect light attenuated by a subject;

generate a positive signal by replacing each negative value of the physiological signal with a predetermined value;

generate a negative signal by replacing each positive value of the physiological signal with a predetermined value;

filter the positive signal to generate a filtered positive signal;

filter the negative signal to generate a filtered negative signal;

combine the filtered positive signal and the filtered negative signal to generate a combined signal;

modify the physiological signal based on the combined signal;

determine a physiological rate of the subject based on the modified physiological signal; and

display the physiological rate of the subject on a display.

9. The processing module of claim 8, further configured to:

generate the positive signal by replacing each negative value of the physiological signal with a zero; and

generating the negative signal by replacing each positive value of the physiological signal with a zero.

10. The processing module of claim 8, further configured to:

low pass filter the positive signal; and

low pass filter the negative signal.

11. The processing module of claim 8, further configured to average the filtered positive signal and the filtered negative signal.

12. The processing module of claim 8, further configured to scale the combined signal prior to modification of the physiological signal based on the combined signal.

13. The processing module of claim 12, further configured to scale the combined signal based on a standard deviation of the combined signal.

14. The processing module of claim 8, further configured to modify the physiological signal by subtracting the combined signal from the physiological signal.

15. A method for determining a physiological rate using a pulse oximeter, comprising:

receiving, using the pulse oximeter, a physiological signal derived from a pulse oximetry sensor, wherein the pulse oximetry sensor detects light attenuated by a subject;

generating, using the pulse oximeter, a positive signal positive by replacing each negative value of the physiological signal with a predetermined value;

generating, using the pulse oximeter, a negative signal based on by replacing each positive value of the physiological signal with a predetermined value;

filtering, using the pulse oximeter, the positive signal to generate a filtered positive signal;

filtering, using the pulse oximeter, the negative signal to generate a filtered negative signal;

combining, using the equipment pulse oximeter, the filtered positive signal and the filtered negative signal to generate a combined signal;

modifying, using the pulse oximeter, the physiological signal based on the combined signal;

determining, using the pulse oximeter, a physiological rate of the subject based on the modified physiological signal; and

displaying, using the pulse oximeter, the physiological rate of the subject on a display.

16. The method of claim 15, wherein generating the positive signal comprises replacing each negative value of the physiological signal with a zero and wherein generating the negative signal comprises replacing each positive value of the physiological signal with a zero.

17. The method of claim 15, wherein filtering the positive signal comprises low pass filtering the positive signal and wherein filtering the negative signal comprises low pass filtering the negative signal.

18. The method of claim 15, wherein combining the filtered positive signal and the filtered negative signal comprises averaging the filtered positive signal and the filtered negative signal.

19. The method of claim 15, further comprising scaling, using the pulse oximeter, the combined signal prior to modifying the physiological signal based on the combined signal.

20. The method of claim 19, wherein scaling the combined signal comprises scaling the combined signal based on a standard deviation of the combined signal.

21. The method of claim 15, wherein modifying the physiological signal comprises subtracting the combined signal from the physiological signal.

22. A non-transitory computer-readable medium for use in determining a physiological rate, the non-transitory computer-readable medium comprising:

computer program instructions recorded thereon for causing a pulse oximeter to;

receive a physiological signal derived from a pulse oximetry sensor, wherein the pulse oximetry sensor detects light attenuated by a subject;

generate a positive signal by replacing each negative value of the physiological signal with a predetermined value;

generate a negative signal by replacing each positive value of the physiological signal with a predetermined value;

filter the positive signal to generate a filtered positive signal;

filter the negative signal to generate a filtered negative signal;

combine the filtered positive signal and the filtered negative signal to generate a combined signal;

modify the physiological signal based on the combined signal;

determine a physiological rate of the subject based on the modified physiological signal; and

display the physiological rate of the subject on a display.

23. The non-transitory computer-readable medium of claim 22, comprising further computer program instructions recorded thereon for causing the pulse oximeter to:

generate the positive signal by replacing each negative value of the physiological signal with a zero; and

generate the negative signal by replacing each positive value of the physiological signal with a zero.

24. The non-transitory computer-readable medium of claim 22, comprising further computer program instructions recorded thereon for causing the pulse oximeter to:

low pass filter the positive signal; and

low pass filter the negative signal.

25. The non-transitory computer-readable medium of claim 22, comprising further computer program instructions recorded thereon for causing the pulse oximeter to average the filtered positive signal and the filtered negative signal.

26. The non-transitory computer-readable medium of claim 22, comprising further computer program instructions recorded thereon for causing the pulse oximeter to scale the combined signal prior to modifying the physiological signal based on the combined signal.

27. The non-transitory computer-readable medium of claim 26, comprising further computer program instructions recorded thereon for causing the pulse oximeter to scale the combined signal based on a standard deviation of the combined signal.

28. The non-transitory computer-readable medium of claim 22, comprising further computer program instructions recorded thereon for causing the pulse oximeter to modify the physiological signal by subtracting the combined signal from the physiological signal.