Liquid pharmaceutical composition for the treatment of a posterior eye disease
First Claim
1. A method for treatment of a tissue associated with a posterior segment of an eye of a patient, comprising periocular injection of a pharmaceutical composition comprising an active ingredient and a non-aqueous, physiologically tolerable, liquid vehicle having a density of at least 1.2 g/ml, wherein the liquid vehicle comprises a semifluorinated alkane.
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Abstract
The invention provides pharmaceutical compositions based on liquid vehicles whose density is substantially higher than that of aqueous physiological fluids. The compositions are useful as medicines in ophthalmology, in particular for the treatment of conditions affecting the posterior segment of an eye. They may be administered topically into the eye or in a minimally invasive manner by periocular injection. Preferred liquid carriers are selected from semifluorinated alkanes.
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Citations
21 Claims
- 1. A method for treatment of a tissue associated with a posterior segment of an eye of a patient, comprising periocular injection of a pharmaceutical composition comprising an active ingredient and a non-aqueous, physiologically tolerable, liquid vehicle having a density of at least 1.2 g/ml, wherein the liquid vehicle comprises a semifluorinated alkane.
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10. The method of 1, wherein the pharmaceutical composition has a dynamic viscosity of not more than about 5 mPa·
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- 15. A method for treating a disease or condition of a tissue associated with a posterior segment of an eye of a patient, comprising (a) administering a pharmaceutical composition comprising an active ingredient and a non-aqueous, physiologically tolerable, liquid vehicle comprising a semifluorinated alkane and having a density of at least 1.2 g/ml, by periocular injection, and subsequently (b) bringing the patient into a supine position facing upwards for a sufficiently long time period to allow the composition to migrate from the periocular site to a site in a posterior segment of the eye.
Specification