System and method for mapping baroreceptors
First Claim
1. A method, comprising:
- placing a set of stimulation electrodes on tissue containing a baroreceptor region;
automatically mapping the baroreceptor region using a controller and at least one physiologic response sensor, including;
testing bipolar configurations of the electrodes, each of the bipolar configurations of the electrodes including at least one of the electrodes configured to function as an anode and at least one other of the electrodes configured to function as a cathode, wherein testing the bipolar configurations includes stimulating the tissue using each of the bipolar configurations;
for each of the tested bipolar configurations monitoring at least one physiological parameter for a baroreflex response to stimulation of the tissue; and
recording the baroreflex response for each of the tested bipolar configurations.
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Accused Products
Abstract
An example of a method embodiment may place a set of stimulation electrodes on tissue containing the baroreceptor region, and may test bipolar configurations of the electrodes. Each of the bipolar configurations of the electrodes includes at least one of the electrodes configured to function as an anode and at least one other of the electrodes configured to function as a cathode. Testing the bipolar configurations may include stimulating the tissue using each of the bipolar configurations. For each of the tested bipolar configurations at least one physiological parameter may be monitored for a baroreflex response to stimulation of the tissue, and the baroreflex response may be recorded for each of the tested bipolar configurations.
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Citations
20 Claims
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1. A method, comprising:
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placing a set of stimulation electrodes on tissue containing a baroreceptor region; automatically mapping the baroreceptor region using a controller and at least one physiologic response sensor, including; testing bipolar configurations of the electrodes, each of the bipolar configurations of the electrodes including at least one of the electrodes configured to function as an anode and at least one other of the electrodes configured to function as a cathode, wherein testing the bipolar configurations includes stimulating the tissue using each of the bipolar configurations; for each of the tested bipolar configurations monitoring at least one physiological parameter for a baroreflex response to stimulation of the tissue; and recording the baroreflex response for each of the tested bipolar configurations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method, comprising:
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placing a set of stimulation electrodes on tissue containing a baroreceptor region; and automatically mapping the baroreceptor region using a controller and at least one physiologic response sensor, including; mapping one or more cathode clusters to confirm at least one of the cathode cluster is proximate to a baroreceptor hotspot, wherein each of the cathode clusters includes three or more of the stimulation electrodes connected to function as a cathode and wherein at least one other of the stimulation electrodes is connected to function as an anode; for each cathode cluster confirmed to be proximate to the baroreceptor hotspot, conducting a secondary mapping to test at least two smaller cathode clusters to confirm at least one of the smaller cathode clusters is proximate to the baroreceptor hotspot; for each smaller cathode cluster confirmed to be proximate to the baroreceptor hotspot, mapping individual cathode electrodes within the smaller cathode cluster to confirm at least one of the individual cathode electrodes is proximate to the baroreceptor hotspot. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A system for mapping a baroreceptor region, comprising:
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stimulation electrodes for placement on tissue containing the baroreceptor region; a stimulator, including a stimulation controller, a pulse generator, and switches, wherein the stimulation controller and switches are configured to connect different combination of the stimulation electrodes to the pulse generator to deliver bipolar stimulation of the tissue; at least one physiologic response sensor configured to sense a physiologic response to stimulation of the tissue; the controller including a stimulation protocol selector configured to select electrode configurations for testing, including control the switches to connect the pulse generator to the stimulation electrodes to provide selected electrode configurations for testing; the controller including a physiologic feedback module to receive a signal from the at least one sensor, and a physiologic parameter analyzer configured to monitor a baroreflex response; and the controller is configured to use the stimulation protocol selector and the physiologic feedback module to map the baroreceptor region, including; stimulate the tissue using bipolar configurations of the electrodes to test the bipolar configurations, each of the bipolar configurations of the electrodes including at least one of the electrodes functioning as an anode and at least one other of the electrodes functioning as a cathode; for each of the tested bipolar configurations monitor at least one physiological parameter for a baroreflex response to stimulation of the tissue; and record the baroreflex response for each of the tested bipolar configurations. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification