ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors
First Claim
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1. An oligonucleotide having the nucleotide sequence as shown in any one of SEQ ID NOS:
- 19, 20, 30, 41, 64, 66, or 87 in the SEQUENCE LISTING, or a pharmacologically acceptable salt thereof, wherein at least one sugar constituting the oligonucleotide is modified and/or at least one phosphate constituting the oligonucleotide is modified.
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Accused Products
Abstract
Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
14 Citations
15 Claims
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1. An oligonucleotide having the nucleotide sequence as shown in any one of SEQ ID NOS:
- 19, 20, 30, 41, 64, 66, or 87 in the SEQUENCE LISTING, or a pharmacologically acceptable salt thereof, wherein at least one sugar constituting the oligonucleotide is modified and/or at least one phosphate constituting the oligonucleotide is modified.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
Specification