Polymers selective for nitro-containing compounds and methods of using the same
First Claim
1. Beads for selectively removing a nitroso-containing compound from material containing the compound and nicotine, said beads comprising an adsorbent polymer of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, said beads having selectivity for said nitroso-containing compound over nicotine.
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Accused Products
Abstract
Porous beads are provided of a polymer of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, further comprising residues of polyvinyl alcohol. The beads may be molecularly imprinted or non-molecularly imprinted. The use of such beads in the removal of nitroso-containing compounds from material containing them is also disclosed. Also disclosed is a non-molecularly imprinted polymer which is selectively adsorbent for at least one tobacco specific nitrosamine in the presence of nicotine, said polymer being a polymerization product of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic.
15 Citations
34 Claims
- 1. Beads for selectively removing a nitroso-containing compound from material containing the compound and nicotine, said beads comprising an adsorbent polymer of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, said beads having selectivity for said nitroso-containing compound over nicotine.
- 20. A method of making beads for selectively removing a nitroso-containing compound from material containing the compound and nicotine, said beads being of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, the method comprising suspension polymerizing a monomer phase comprising initiator, the non-acidic monomer and the cross-linker having polar functionality in an aqueous phase, said beads having selectivity for said nitroso-containing compound over nicotine.
- 26. A method for selectively removing a nitroso-containing compound from material containing the compound and nicotine, said method comprising contacting the material with an aqueous phase comprising beads of a selectively adsorbent polymer of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, said beads having selectivity for said nitroso-containing compound over nicotine.
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32. A tobacco product, smoking article or smoke filter comprising tobacco and porous beads for selectively removing a nitroso-containing compound from material containing the compound and nicotine, said beads being of a selectively adsorbent polymer of a non-acidic monomer and a cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, said beads having selectivity for said nitroso-containing compound over nicotine.
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33. A kit comprising beads for selectively removing a nitroso-containing compound from material containing the compound and nicotine, said beads comprising a polymer of a non-acidic monomer and cross-linker having polar functionality, one of which is hydrophilic, the other of which is hydrophobic, and being selective relative to nicotine for at least one nitroso-containing compound, and further comprising one or more of the following items:
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(a) instructions for using the beads to perform at least one of analysing, detecting, quantifying, separating, extracting, reducing or removing nitroso-containing compounds in or from a sample; (b) a column for solid phase extraction (“
SPE”
), chromatography or other filtration techniques;(c) a quantity of any of the foregoing beads divided into discrete quantities suitable for loading into the filtration column; (d) an SPE, chromatography or other filtration column packed with a quantity of any of the foregoing beads; (e) reagents for conditioning the column; (f) reagents for eluting the column and re-generating the beads; and (g) one or more of a spatula, measuring cylinder, beaker or other tool for handling the ingredients. - View Dependent Claims (34)
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Specification