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Saliva glucose monitoring system

  • US 9,244,035 B2
  • Filed: 01/13/2014
  • Issued: 01/26/2016
  • Est. Priority Date: 01/11/2013
  • Status: Active Grant
First Claim
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1. A glucose sensor for determining a concentration of glucose in a liquid sample, the sensor comprising:

  • an insulating or semiconducting substrate;

    at least one working electrode, a counter electrode, and a reference electrode, anda sample placement area on a surface of the substrate for containing the liquid sample during a determination of the glucose concentration in the liquid sample;

    wherein each of the working electrode(s), counter electrode, and reference electrode comprises a conductive metal layer deposited on the substrate in the sample placement area;

    wherein the working electrode is coated in the sample placement area with a plurality of sensor elements;

    wherein the sensor elements in the sample placement area are functionalized with a functionalization coating comprising from 2 to 10 layers, each layer comprising a sublayer of chitosan, a sublayer of gold nanoparticles deposited onto the chitosan, and a sublayer of glucose oxidase deposited onto the gold nanoparticles;

    wherein the working electrode, counter electrode, and reference electrode are connected to an amperometry circuit;

    wherein the sensor measures electron transfer through the glucose oxidase into the working electrode; and

    wherein an output voltage of the amperometry circuit correlates with a glucose concentration in the liquid sample deposited in the sample placement area.

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