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Systems, devices, and methods for agglutination assays using sedimentation

  • US 9,244,065 B1
  • Filed: 03/16/2012
  • Issued: 01/26/2016
  • Est. Priority Date: 03/16/2012
  • Status: Active Grant
First Claim
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1. A method comprising:

  • layering a mixture on a density medium, wherein the mixture includes a sample and a first population of coated beads having a first density, wherein the first population of coated beads include affinity reagents for an analyte of interest, wherein the first population of coated beads is configured to form aggregates with the analyte interest when present, wherein the density medium has a minimum density greater than the first density;

    subjecting the mixture to sedimentation forces such that the aggregates, if formed, travel through the density medium; and

    detecting a presence of the aggregates in a detection area.

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