Medical devices for controlled drug release
First Claim
1. A medical device for controlling the release of an active agent, the medical device comprising:
- a supporting structure configured and dimensioned to be used within a body of a human or an animal;
a porous body disposed on and at least partially covering the supporting structure, said porous body being constructed of a first biocompatible material and said porous body having a plurality of pores, the first biocompatible material being a metal, a ceramic, or a combination of metal and ceramic;
a therapeutically effective amount of an active agent disposed within the pores; and
an elution rate controlling matrix within the pores to contain the active agent, said matrix comprising a second biocompatible material that controls an elution rate of the active agent from the pores; and
wherein the second biocompatible material is biodegradable and degrades in a period less than five years upon exposure to a physiological solution, and each pore comprises an upper volume and a lower volume, the active agent occupies the upper volume and the lower volume, and the upper volume is separated from the lower volume by an intermediate layer of the matrix.
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Accused Products
Abstract
The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.
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Citations
13 Claims
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1. A medical device for controlling the release of an active agent, the medical device comprising:
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a supporting structure configured and dimensioned to be used within a body of a human or an animal; a porous body disposed on and at least partially covering the supporting structure, said porous body being constructed of a first biocompatible material and said porous body having a plurality of pores, the first biocompatible material being a metal, a ceramic, or a combination of metal and ceramic; a therapeutically effective amount of an active agent disposed within the pores; and an elution rate controlling matrix within the pores to contain the active agent, said matrix comprising a second biocompatible material that controls an elution rate of the active agent from the pores; and wherein the second biocompatible material is biodegradable and degrades in a period less than five years upon exposure to a physiological solution, and each pore comprises an upper volume and a lower volume, the active agent occupies the upper volume and the lower volume, and the upper volume is separated from the lower volume by an intermediate layer of the matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification