Compositions and methods for inhibition of the JAK pathway
First Claim
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1. A method of inhibiting a signal transduction cascade in which JAK3 kinase plays a role, comprising contacting a cell expressing a receptor involved in such a signaling cascade with a compound having formula II, or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the signal transduction cascade
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Abstract
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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7 Claims
- 1. A method of inhibiting a signal transduction cascade in which JAK3 kinase plays a role, comprising contacting a cell expressing a receptor involved in such a signaling cascade with a compound having formula II, or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the signal transduction cascade
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2. A pharmaceutical formulation, comprising:
a compound having formula II, or a pharmaceutically acceptable salt thereof, - View Dependent Claims (6, 7)
Specification