Composite particles for use in oral hygiene

• US 9,248,319 B2
• Filed: 08/06/2010
• Issued: 02/02/2016
• Est. Priority Date: 08/08/2009
• Status: Active Grant

• Current Assignee: Evonik Operations GmbH (Rag-Stiftung)
• Original Assignee: Evonik Degussa GmbH (Rag-Stiftung)
• Inventors: Pisula, Wojciech, Tschernjaew, Juri, Storeck, Arnold, Hahn, Rainer, Schffer, Stephanie
• Primary Examiner(s): Maewall, Snigdha
• Application Number:
  US12/851,623
• Publication Number:
  US 20110033511A1
• Time in Patent Office: 2,006 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0279 Porous; Hollow
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/733 Alginic acid; Salts thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The present invention relates to functional composite particles for the oral care sector, more particularly for toothpastes and mouthwashes, which are charged with active ingredients which ensure a long-term antimicrobial or antibacterial effect in the oral cavity and hence reduce the formation of plaque and halitosis. The invention further relates to a process for producing these composite particles and also to their use for producing oral hygiene articles.

Claims

1. Composite particles as additives for toothpaste and mouthwash, wherein the particles comprise

a porous carrier of amorphous SiO₂, having an average particle size of 3 to 50 pm, and a specific surface area of between 50 and 550 m²/g,

at least one active ingredient, or a combination thereof

and at least one envelope material, wherein the at least one envelope material releases an active ingredient following activation in the oral chamber,

wherein the weight ratio of the envelope material or the sum of the envelope materials to the active ingredient or the sum of the active ingredients is in the range from 10:

1 to 1;

10,

wherein at least one envelope material is selected such that the active ingredient is released in the oral cavity by diffusion, pH change, enzymatic degradation of the envelope material, temperature change, ion exchange or dissolution of the envelope material

and wherein, as demonstrated by XPS analysis of the outermost atomic layers of the composite particles, the porous carrier is not completely encapsulated by the envelope material, and at least 10% of the outer surfaces of the composite particles are formed by the porous carrier.

2. Composite particles according to claim 1, wherein at least one envelope material is a mucoadhesive envelope material, an envelope material having antibacterial effect, an envelope material having antimicrobial effect, or a combination thereof.

3. Composite particles according to claim 1, wherein at least one envelope material releases an active ingredient following activation in the oral chamber.

4. Composite particles according to claim 1, wherein the particles comprise at least one mucoadhesive envelope material and at least one non-mucoadhesive envelope material.

5. Composite particles according to claim 1, wherein the envelope material is an envelope material selected from polysaccharides, poly(meth)acrylates, polyelectrolytes, and fatty acids.

6. Composite particles according to claim 1, wherein at least one active ingredient has antibacterial, antimicrobial, odorizing or flavoring properties.

7. Process for producing composite particles according to claim 1, wherein at least one porous carrier of amorphous SiO₂ is contacted with at least one envelope material or with at least one active ingredient and at least one envelope material.

8. Process according to claim 7, wherein at least one active ingredient is contacted with the porous carrier of amorphous SiO₂ in such a way that the active ingredient is drawn into the pores of the porous carrier.

9. Process according to claim 1, comprising the following steps:

a) introducing at least one porous carrier of amorphous SiO₂ in a solids mixing unit

g) adding at least one envelope material

h) impregnating the porous carrier with at least one envelope material.

10. Process according to claim 9, further comprising at least one of the following steps:

b) evacuating the solids mixing unit

c) preimpregnating the porous carrier with at least one envelope material up to a maximum of 50% by weight of the DBP absorption value

d) adding at least one active ingredient to the solids mixing unit

e) impregnating the porous carrier with active ingredient

i) washing, drying, or a combination thereof

f) inhibiting the active ingredient adhering to the outer particle surface of the porous carrier, washing, drying, or a combination thereof

j) reactively inhibiting the active ingredient adhering to the outer particle surface of the porous carrier, washing, drying, or a combination thereof.

11. Process according to claim 10, wherein steps b) to e), steps g) to h), or a combination thereof, are carried out repeatedly, it being possible, on repetition of steps d) and e), steps g) and h), or a combination thereof, to use identical or different active ingredients, envelope materials, or a combination thereof in each case.

12. Process according to claim 9, wherein the porous carrier and at least one active ingredient are mixed before being introduced into the solids mixing unit.

13. Process according to claim 9, wherein the amount of at least one envelope substance added in step g) is regulated such that the total amount of at least one active ingredient and at least one envelope material added in the production of the composite particles is 50% to 100% by weight of the DBP absorption value of the porous carrier.

14. Process according to claim 9, wherein the amount of at least one envelope material added in step g) is regulated such that the total amount of at least one active ingredient and at least one envelope material added in the production of the composite particles is greater than the total pore volume of the porous carrier, and the excess of at least one envelope material is absorbed by addition of porous carrier, porous carrier charged with at least one active ingredient, or a combination thereof.

15. Process according to claim 7, wherein the envelope material is a polysaccharide which is gelled following application to the porous carrier.

16. Oral hygiene article comprising at least one composite particle according to claim 1.

17. Oral hygiene article according to claim 16, wherein the article is selected from toothpaste and mouthwash.

18. Method of producing an article for oral hygiene, comprising incorporating composite particles according to claim 1 into the article.

19. Method according to claim 18, wherein the article is selected from toothpaste and mouthwash.