System for blood separation with a separation chamber having an internal gravity valve

• US 9,248,446 B2
• Filed: 02/13/2014
• Issued: 02/02/2016
• Est. Priority Date: 02/18/2013
• Status: Active Grant

• Current Assignee: Terumo BCT, Inc. (Terumo Corporation)
• Original Assignee: Terumo BCT, Inc. (Terumo Corporation)
• Inventors: Kolenbrander, Jeremy P., Uhl, Geoffrey
• Primary Examiner(s): White, Dennis M
• Assistant Examiner(s): KILPATRICK, BRYAN T
• Application Number:
  US14/179,955
• Publication Number:
  US 20140234183A1
• Time in Patent Office: 719 Days
• Field of Search: 422/533, 494/4, 435/2
• US Class Current: 1/1
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362262 Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362265 Details of valves
• CPC Class Codes: A61M 1/362266 Means for adding solutions or substances to the blood
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 1/3698 Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
• CPC Class Codes: A61M 1/38 Removing constituents from donor blood and storing or returning remainder to body , e.g. for transfusion
• CPC Class Codes: B01D 21/26 Separation of sediment aided by centrifugal force or centripetal forcecentrifuges B04B; cyclones B04C
• CPC Class Codes: B01L 3/5021 Test tubes specially adapted for centrifugation purposes centrifuges B04B5/04
• CPC Class Codes: B04B 2005/0471 with additional elutriation separation of different particles
• CPC Class Codes: B04B 5/0442 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation

Abstract

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, an outlet and a gravity valve inside the cell separation chamber. The valve is responsive to the gravitational field created by the speed of the rotor. When the rotor spins at high speed, the gravity valve may open the outlet at a location proximal to an axis of rotation of the rotor. When the rotor spins at a lower speed, the gravity valve may open the outlet at a location distal from the axis.

Claims

1. A disposable cell separation set comprising

a fluidized-bed cell separation chamber adapted to be mounted on a centrifugal apparatus, said cell separation chamber having a generally conically main body, said main body being symmetrical around an axis with an inlet at an apex of the conically shaped main body and an outlet centrally located at a base of the main body, and

an internal gravity valve mounted within said separation chamber and integral with said separation chamber, said gravity valve selectively allowing fluid flow through a first flow path near said inlet to said outlet and alternatively through a second flow path near said outlet of said separation chamber to said outlet.

2. The disposable cell separation set according to claim 1 wherein said gravity valve comprises a rod adapted to be displaced from said outlet toward said inlet centrally positioned around said axis.

3. The disposable cell separation set of claim 2 wherein said rod has a bore extending from a first end of the rod and one or more vents at a stopped end of said bore, whereby said bore and said one or more vents provide a fluid path into said separation chamber.

4. The disposable cell separation set of claim 3 further comprising a pipe extending from said inlet to a location near said vents in said rod, allowing fluid to flow from said inlet, through the pipe, out the vents and into the cell separation chamber.

5. The disposable cell separation set of claim 4 wherein said rod also comprises one or more conduits extending from the distal end to a proximal end of the rod.

6. The disposable cell separation set of claim 5 wherein the conduits are in fluid connection with the interior of the separation chamber through orifices at the first end of the rod and through a cavity at the second end to the rod.

7. The disposable cell separation set of claim 2 further comprising at least one spring acting on the rod of the gravity valve.

8. The disposable cell separation set of claim 2 wherein said rod comprises a lumen extending from a distal end to a proximal end of said rod.

9. The disposable cell separation set of claim 8 wherein said separation chamber further comprises a cup detachably supporting said distal end of said rod, said cup being affixed to said main body of said separation chamber between said inlet and said outlet.

10. The disposable cell separation set of claim 9 wherein said cup is mounted in a disc, said disc having at least one opening therein.