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Methods of manufacturing contact lenses for delivery of beneficial agents

  • US 9,248,928 B2
  • Filed: 12/18/2013
  • Issued: 02/02/2016
  • Est. Priority Date: 12/21/2012
  • Status: Active Grant
First Claim
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1. A method of manufacturing a contact lens, said method comprising:

  • a) polymerizing a monomer mixture comprising at least one carboxylic-acid containing monomer to form a lens-shaped polymerization product comprising carboxylic acid groups;

    b) placing the lens-shaped polymerization product in a package containing a packaging solution comprising a buffer and a beneficial cationic agent, wherein said packaging solution has an osmolality of about 200 to about 400 mOsm/kg, and wherein said packaging solution i) has an ionic strength of less than about 0.1, or ii) is temperature-sensitive, or iii) has an ionic strength of less than about 0.1 and is temperature-sensitive; and

    c) sealing and autoclaving the package to provide a sterile packaged contact lens, wherein the beneficial cationic agent ionically binds to the carboxylic acid groups and releases from the contact lens in an in vitro release assay;

    wherein at least 50% more of the cationic agent is taken up by the lens compared to an identical contact lens packaged in PBS.

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