Long-acting coagulation factors and methods of producing same
First Claim
1. A method of reducing excessive bleeding in a subject, the method comprising the step of administering a pharmaceutical composition comprising a CTP-modified activated Factor VII (FVIIa) polypeptide to the subject, wherein said CTP-modified activated Factor VII (FVIIa) polypeptide comprises a FVII polypeptide and three to five chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said CTP-modified FVII polypeptide, thereby reducing excessive bleeding in said subject.
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Abstract
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
129 Citations
25 Claims
- 1. A method of reducing excessive bleeding in a subject, the method comprising the step of administering a pharmaceutical composition comprising a CTP-modified activated Factor VII (FVIIa) polypeptide to the subject, wherein said CTP-modified activated Factor VII (FVIIa) polypeptide comprises a FVII polypeptide and three to five chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said CTP-modified FVII polypeptide, thereby reducing excessive bleeding in said subject.
- 15. A method of reducing excessive bleeding in a subject, the method comprising the step of administering to the subject a pharmaceutical composition comprising a CTP-modified Factor IX (FIX) polypeptide, wherein said CTP-modified Factor IX (FIX) polypeptide comprises a FIX polypeptide and three to five chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said CTP-modified Factor IX (FIX) polypeptide, thereby reducing excessive bleeding in said subject.
Specification