Oligonucleotide compounds comprising non-nucleotide overhangs
First Claim
Patent Images
1. A double-stranded nucleic acid molecule comprising a sense strand sequence 5′
- CAGAAGUCAUCUUGCUACA 3′
(SEQ ID NO.
9) and an antisense strand sequence 5′
UGUAGCAAGAUGACUUCUG 3′
(SEQ ID NO.
10);
or a pharmaceutically acceptable salt of such molecule.
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Abstract
The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions.
49 Citations
20 Claims
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1. A double-stranded nucleic acid molecule comprising a sense strand sequence 5′
- CAGAAGUCAUCUUGCUACA 3′
(SEQ ID NO.
9) and an antisense strand sequence 5′
UGUAGCAAGAUGACUUCUG 3′
(SEQ ID NO.
10);
or a pharmaceutically acceptable salt of such molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- CAGAAGUCAUCUUGCUACA 3′
Specification