Method for assembly of spectroscopic filter arrays using biomolecules
First Claim
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1. An imaging system for electromagnetic radiation, comprising:
- (1) a photodetector array; and
(2) a microarray on a substrate comprising a plurality of addressable regions, each addressable region having a first layer comprising;
(a) a first nucleic acid moiety attached to the substrate; and
(b) a first plurality of filter particles having attached thereto a second nucleic acid moiety capable of hybridizing to the first nucleic acid moiety on a selected addressable region of the microarray; and
wherein at least one addressable region further comprises a second layer comprising;
a second plurality of filter particles having attached thereto a third nucleic acid moiety capable of hybridizing to the second nucleic acid moiety; and
wherein the layers of filter particles in at least two addressable regions are configured to allow passage of different selected wavelengths of electromagnetic radiation through the filter particles; and
wherein the photodetector array is configured to detect at least one wavelength of electromagnetic radiation that has passed through the filter particles.
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Abstract
Spectroscopic filter arrays and methods for making spectroscopic filter arrays are provided. The arrays are formed using a dispersion of filter particles having selected moieties attached to the surface of the particles and a microarray having complementary moieties formed in an array on a substrate, such that each filter particle is attached to a selected region of the microarray. The moiety on the substrate may be RNA or DNA or other molecule. The substrate may be a surface of a photodetector array, a transparent plate that may be placed in registration with the photodetector or a stamp used to transfer the filter array to a photodetector array.
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Citations
25 Claims
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1. An imaging system for electromagnetic radiation, comprising:
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(1) a photodetector array; and (2) a microarray on a substrate comprising a plurality of addressable regions, each addressable region having a first layer comprising; (a) a first nucleic acid moiety attached to the substrate; and (b) a first plurality of filter particles having attached thereto a second nucleic acid moiety capable of hybridizing to the first nucleic acid moiety on a selected addressable region of the microarray; and wherein at least one addressable region further comprises a second layer comprising; a second plurality of filter particles having attached thereto a third nucleic acid moiety capable of hybridizing to the second nucleic acid moiety; and wherein the layers of filter particles in at least two addressable regions are configured to allow passage of different selected wavelengths of electromagnetic radiation through the filter particles; and wherein the photodetector array is configured to detect at least one wavelength of electromagnetic radiation that has passed through the filter particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification