Detection and monitoring using high frequency electrogram analysis

• US 9,254,094 B2
• Filed: 06/09/2015
• Issued: 02/09/2016
• Est. Priority Date: 06/09/2013
• Status: Active Grant

• Current Assignee: BSP Medical Limited
• Original Assignee: Bsp Biological Signal Processing Ltd.
• Inventors: Ben-David, Tamir, Granot, Yair, Beker, Amir
• Primary Examiner(s): Stigell, Theodore
• Assistant Examiner(s): CAREY, MICHAEL JAMES
• Application Number:
  US14/734,032
• Publication Number:
  US 20150272463A1
• Time in Patent Office: 245 Days
• Field of Search: 600/516, 600/509, 600/517, 600/521
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An implantable device for analyzing a high frequency (HF) electrogram signal including an implantable electrode, a signal pickup configured to pick up an electrogram signal including a HF component, a signal filter connected to the signal pickup and configured to measure a HF component from the signal only during a specific portion of a cardiac cycle, and an analyzer for analyzing the HF component, wherein the signal pickup, the signal filter and the analyzer are included within an implantable container, and the analyzer is configured to analyze at least one time-varying parameter of the HF component, and the signal filter is configured to measure the signal by using a signal picked up from at least one electrode selected from a group consisting of (a) intracardiac, (b) subcutaneous, (c) a can of the implanted device, (d) a combination of two of the above. Related apparatus and methods are also described.

Claims

1. An implantable device for analyzing a high frequency (HF) electrogram signal comprising:

an implantable electrode for use inside a living body;

a signal pickup configured to pick up an electrogram signal comprising a high frequency (HF) component;

a signal filter connected to the signal pickup and configured to measure a high frequency (HF) component from the electrogram signal only during a specific portion of a cardiac cycle; and

an analyzer for analyzing the HF component of the electrogram signal,

wherein;

the signal pickup, the signal filter and the analyzer are comprised within an implantable container; and

the analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal; and

the signal filter is configured to measure said electrogram signal by using a signal picked up from at least one electrode selected from a group consisting of;

(a) an intracardiac electrode;

(b) a subcutaneous electrode;

(c) a can of said implanted device;

(d) a combination of two of the above.

2. The device of claim 1 in which the specific portion of the cardiac cycle comprises at least part of a specific segment of the cardiac cycle, the specific segment of the cardiac cycle being one of a group consisting of:

a P segment;

a Q segment;

a R segment;

a S segment;

a T segment; and

a QRS complex segment.

3. The device of claim 1 in which said signal filter is arranged to start measuring said electrogram signal a specific period of time following a synchronizing pacing signal.

4. The device of claim 1 in which the analyzer is configured to detect a change in the time-varying parameter in comparison to a baseline value of the time-varying parameter.

5. The device of claim 1 in which:

the specific segment of the cardiac cycle is a P segment; and

the analyzer is configured to provide indication of atrial arrhythmia,

and further comprising a pacing unit for manipulating a pacing rate, based on the indication, to overcome the atrial arrhythmia.

6. The device of claim 1 in which:

the specific segment of the cardiac cycle is a QRS complex; and

the analyzer is configured to provide indication of onset of an ischemic event,

and further comprising a pacing unit arranged to manipulate a pacing rate, based on the indication, to overcome the onset of the ischemic event by reducing the pacing rate.

7. A method for analyzing a high frequency (HF) electrogram signal comprising:

(a) providing at least one electrogram signal from an electrode located within a subject'"'"'s body;

(b) measuring the electrogram signal at a high frequency only during a specific portion of a cardiac cycle, generating a HF electrogram signal for the specific portion of the cardiac cycle; and

(c) calculating at least one time-varying parameter of the generated HF electrogram signal,

wherein the specific portion of the cardiac cycle comprises at least part of a specific segment of the cardiac cycle, the specific segment of the cardiac cycle being one of a group consisting of;

a P segment;

a Q segment;

a R segment;

a S segment;

a T segment; and

a QRS complex segment.

8. The method of claim 7 in which the providing at least one electrogram signal from an electrode located within a subject'"'"'s body comprises measuring an electrogram signal by using at least one electrode selected from a group consisting of:

(a) an intracardiac electrode;

(b) a subcutaneous electrode;

(c) a can of an implanted device;

(d) a combination of two of the above.

9. The method of claim 7 in which the specific segment of the cardiac cycle is a P segment, and the analysis is used to provide warning of a condition selected from a group consisting of:

an irregular propagation of an action potential in a cardiac atria;

atrial tachycardia;

atrial bradycardia; and

atrial arrhythmia.

10. The method of claim 7 in which:

the specific segment of the cardiac cycle is a P segment; and

the analysis is used to provide warning of atrial arrhythmia,

and further comprising manipulating a pacing rate to overcome the atrial arrhythmia.

11. The method of claim 7 in which the specific segment of the cardiac cycle comprises a QRS complex, and the analysis is used to provide warning of onset of an ischemic event.

12. The method of claim 11 in which the analysis comprises detection of a reduction in amplitude of the HF electrogram signal.

13. The method of claim 7 in which the sampling of the electrogram signal at a high frequency comprises sampling the electrogram signal at a high frequency during a specific segment of a breathing cycle.

14. The method of claim 7 and further comprising aligning and averaging a plurality of HF electrogram signals in which the aligning comprises synchronization of HF electrogram signals based on a pacing signal.

15. The method of claim 7 and further comprising comparing a value of the time-varying parameter of the HF electrogram signal and a baseline value of the time-varying parameter of the HF electrogram signal.

16. The method of claim 7 and further comprising comparing a value of the time-varying parameter of the HF electrogram signal and a prior value of the of the time-varying parameter of the HF electrogram signal under same heart rate conditions.

17. The method of claim 16 in which the same conditions are selected from a group consisting of:

(a) same heart rate;

(b) same heart rate increase;

(c) same heart rate decrease;

(d) same pattern of change of heart rate.

18. The method of claim 7 and further comprising comparing a current value of the time-varying parameter of the HF electrogram signal and a prior value of the of the time-varying parameter of the HF electrogram signal in which the prior value was measured for a heart rate different by a pre set amount from a heart rate at which the prior value was measured.

19. An implantable device for analyzing a high frequency (HF) electrogram signal comprising:

an implantable electrode for use inside a living body;

a signal pickup configured to pick up an electrogram signal comprising a high frequency (HF) component;

a measurement unit for measuring a high frequency (HF) component of the electrogram signal only during a specific segment of a breathing cycle; and

an analyzer for analyzing the HF component of the electrogram signal,

wherein;

the signal pickup, the measurement unit and the analyzer are comprised within an implantable container;

the analyzer is configured to analyze at least one time-varying parameter of the HF component of the electrogram signal; and

the analyzer is configured to determine the specific segment of the breathing cycle.

20. A method for analyzing a high frequency (HF) electrogram signal comprising:

(a) providing at least one electrogram signal from an electrode located within a subject'"'"'s body;

(b) measuring the electrogram signal at a high frequency only during a specific segment of a breathing cycle, generating a HF electrogram signal for the specific segment of the breathing cycle; and

(c) having a computer measure at least one time-varying parameter of the HF electrogram signal.