VOA generation system and method using a fiber specific analysis
First Claim
1. A computer system for generating an estimated volume of activation (VOA), the system comprising:
- a computer processor configured to;
for each of a plurality of neural elements that are in a vicinity of a leadwire;
determine a parameter that characterizes the respective neural element;
based on the determined parameter, select one or more of a plurality of parameters that are each stored in association with a respective threshold activation value;
based on the selected one or more of the plurality of stored parameters and the associated one or more respective threshold activation values, set a respective threshold activation value of the respective neural element, wherein the respective neural element becomes activated at the respective threshold activation value and is not activated below the respective threshold activation value; and
determine whether a user-input stimulation value to be applied to the leadwire meets the respective threshold activation value set for the respective neural element; and
generate a surface structure corresponding to those of the neural elements whose respective threshold activation values have been determined to be met by the user-input stimulation value.
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Abstract
A system and method for generating an estimated volume of activation (VOA) corresponding to settings applied to a stimulation leadwire includes a processor performing the following: determining, for each of a plurality of neural elements, one or more respective parameters characterizing an electrical distribution along the neural element, looking up the one or more parameters for each of the neural elements in a look-up table (LUT), obtaining threshold values for each of the neural elements recorded in the LUT in association with the looked-up parameters, comparing, for each of the neural elements, a value of the leadwire settings to each of the respective threshold value, estimating based on the comparisons which of the neural elements would be activated by the settings, and generating a structure corresponding to a region including the neural elements estimated to be activated.
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Citations
39 Claims
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1. A computer system for generating an estimated volume of activation (VOA), the system comprising:
a computer processor configured to; for each of a plurality of neural elements that are in a vicinity of a leadwire; determine a parameter that characterizes the respective neural element; based on the determined parameter, select one or more of a plurality of parameters that are each stored in association with a respective threshold activation value; based on the selected one or more of the plurality of stored parameters and the associated one or more respective threshold activation values, set a respective threshold activation value of the respective neural element, wherein the respective neural element becomes activated at the respective threshold activation value and is not activated below the respective threshold activation value; and determine whether a user-input stimulation value to be applied to the leadwire meets the respective threshold activation value set for the respective neural element; and generate a surface structure corresponding to those of the neural elements whose respective threshold activation values have been determined to be met by the user-input stimulation value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26)
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24. The system of 22, wherein:
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the selected one or more of the plurality of parameters includes a plurality of characterization parameters to which the determined parameter characterization of the respective neural element is not an exact match; and the respective threshold activation value of the respective neural element is determined by interpolating the selected plurality of parameters.
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27. A computer system for generating an estimated volume of activation (VOA), the system comprising:
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a computer processor configured to; for each of a plurality of neural elements that are in a vicinity of a leadwire; determine a respective threshold activation value, wherein the respective neural element becomes activated at the respective threshold activation value and is not activated below the respective threshold activation value; and determine whether a user-input stimulation value to be applied to the leadwire meets the respective threshold activation value of the respective neural element; and
generate a surface structure corresponding to those of the neural elements whose respective threshold activation values have been determined to be met by the user-input stimulation value;wherein one of; (A) the processor is configured to select a first grid that is of a first size based on the user-input stimulation value, the determination of whether the user-input stimulation value meets the respective threshold is initially performed for neural elements positioned at a perimeter of the selected first grid, and, in response to a determination that the user-input stimulation value meets the respective threshold activation value of one of the neural elements positioned at the perimeter of the selected value, the processor is configured to select a second grid of a second size that is larger than the first size; and (B) the processor is configured to selectively apply a marching cubes algorithm to only each pair of adjacent ones of the plurality of neural elements that includes one neural element whose respective threshold activation value is met by the user-input stimulation value and one neural element whose respective threshold activation value is not met by the user-input stimulation value, and the generation of the surface structure is based in part on a result of the applied marching cubes algorithm. - View Dependent Claims (28, 29)
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30. A computer system for generating an estimated volume of activation (VOA), the system comprising:
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a computer processor configured to; for each of a plurality of neural elements that are in a vicinity of a leadwire; determine a respective threshold activation value, wherein the respective neural element becomes activated at the respective threshold activation value and is not activated below the respective threshold activation value; and determine whether a user-input stimulation value to be applied to the leadwire meets the respective threshold activation value of the respective neural element; and generate a surface structure corresponding to those of the neural elements whose respective threshold activation values have been determined to be met by the user-input stimulation value; wherein, for each of the plurality of neural elements, the determination of the respective threshold value includes; determining at least one respective parameter that characterizes at least one of a spread and a height of a distribution of electrical values along the respective neural element; and obtaining the respective threshold value based on the respective determined parameter. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification