Central base coils for deep transcranial magnetic stimulation

• US 9,254,394 B2
• Filed: 02/21/2013
• Issued: 02/09/2016
• Est. Priority Date: 02/21/2013
• Status: Active Grant

• Current Assignee: Brainsway, Ltd.
• Original Assignee: Brainsway, Ltd.
• Inventors: Zangen, Abraham, Roth, Yiftach
• Primary Examiner(s): Matthews, Christine H
• Assistant Examiner(s): LANNU, JOSHUA DARYL DEANON
• Application Number:
  US13/772,442
• Publication Number:
  US 20140235928A1
• Time in Patent Office: 1,083 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/008 for pain treatment or analgesia
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.

Claims

1. A coil for magnetic stimulation, the coil comprising:

a base portion including

a central axis defining a base portion right side and a base portion left side, wherein said base portion right side is positioned on a right side of said central axis and said base portion left side is positioned on a left side of said central axis,

multiple right side stimulating elements, said right side stimulating elements positioned in said base portion right side, wherein said multiple right side stimulating elements are substantially parallel to one another, said multiple right side stimulating elements configured to carry electrical current in substantially a first direction, and

multiple left side stimulating elements, said left side stimulating elements positioned in said base portion left side, wherein said multiple left side stimulating elements are substantially parallel to one another, said multiple left side stimulating elements configured to carry electrical current in substantially said first direction; and

a return portion including

multiple right side return elements positioned on the right side of said central axis, wherein each of said right side return elements corresponds to one of said multiple right side stimulating elements and wherein each of said right side return elements is positioned further away from said central axis than its corresponding right side stimulating element, wherein said multiple right side return elements are substantially parallel to one another, and wherein each of said multiple right side return elements is configured to carry electrical current in substantially a second direction, wherein said second direction is an opposite direction to said first direction, and

multiple left side return elements positioned on the left side of said central axis, wherein each of said left side return elements corresponds to one of said multiple left side stimulating elements and wherein each of said left side return elements is positioned further away from said central axis than its corresponding left side stimulating element, wherein said multiple left side return elements are substantially parallel to one another, and wherein each of said multiple left side return elements is configured to carry electrical current in substantially said second direction,

wherein said return portion is spaced a distance away from said base portion.

2. The coil of claim 1, wherein said multiple right side stimulating elements includes a number of elements which is equal to a number of said multiple left side stimulating elements.

3. The coil of claim 1, wherein said multiple right side stimulating elements are spaced apart from one another and wherein said multiple left side stimulating elements are spaced apart from one another.

4. The coil of claim 3, wherein said multiple right side stimulating elements are spaced variably from one another.

5. The coil of claim 4, wherein said multiple right side stimulating elements include multiple right side groupings of stimulating elements, and wherein said multiple right side groupings are spaced apart from one another.

6. The coil of claim 5, wherein said multiple right side groupings are spaced variably from one another.

7. The coil of claim 5, wherein said multiple right side groupings are spaced uniformly from one another.

8. The coil of claim 3, wherein said multiple left side stimulating elements are spaced variably from one another.

9. The coil of claim 8, wherein said multiple left side stimulating elements include multiple left side groupings of stimulating elements, and wherein said multiple left side groupings are spaced apart from one another.

10. The coil of claim 9, wherein said multiple left side groupings are spaced variably from one another.

11. The coil of claim 9, wherein said multiple left side groupings are spaced uniformly from one another.

12. The coil of claim 1, wherein said multiple right side return elements are spaced apart from one another and wherein said multiple left side return elements are spaced apart from one another.

13. The coil of claim 1, wherein at least one of:

some of said multiple right side return elements are configured to contact a body part and some of said multiple right side return elements are configured to be placed at a distance from a body part and all of said left side return elements are configured to contact a body part;

some of said multiple right side return elements are configured to contact a body part and some of said multiple right side return elements are configured to be placed at a distance from a body part and all of said left side return elements are configured to be placed at a distance from a body part;

some of said multiple left side return elements are configured to contact a body part and some of said multiple left side return elements are configured to be placed at a distance from a body part and all of said right side return elements are configured to contact a body part; and

some of said multiple left side return elements are configured to contact a body part and some of said multiple left side return elements are configured to be placed at a distance from a body part and all of said right side return elements are configured to be placed at a distance from a body part.

14. The coil of claim 1, wherein at least one of:

some of said multiple right side return elements and some of said multiple left side return elements are configured to contact a body part;

some of said multiple right side return elements and some of said multiple left side return elements are configured to be placed at a distance from a body part;

all of said multiple right side return elements and said left side return elements are configured to contact a body part; and

all of said multiple right side return elements and said left side return elements are configured to be placed at a distance from a body part.

15. The coil of claim 1, wherein said base portion includes a first base portion and a second base portion, wherein said first base portion includes a first central axis, said multiple right side stimulating elements on a right side of said first central axis, and said multiple left side stimulating elements on a left side of said first central axis, and wherein said second base portion includes a second central axis, additional multiple right side stimulating elements on a right side of said second central axis, and additional multiple left side stimulating elements on a left side of said second central axis.

16. The coil of claim 15, wherein said first central axis runs along a different direction than said second central axis.

17. The coil of claim 16, wherein said first central axis is substantially perpendicular to said second central axis.

18. The coil of claim 1, further comprising:

a right side connecting portion including multiple right side connecting elements positioned on the right side of the central axis, wherein each of said right side connecting elements is configured to carry electrical current from one of said multiple right side stimulating elements to the corresponding right side return element in a first rotational direction; and

a left side connecting portion including multiple left side connecting elements positioned on the left side of the central axis, wherein each of said left side connecting elements is configured to carry electrical current from one of said multiple left side stimulating elements to the corresponding left side return element in a second rotational direction which is opposite the first rotational direction.

19. A method for treating a neurophysiological condition, the method comprising:

identifying a subject suffering from a neurophysiological condition;

placing a coil on said subject'"'"'s head, the coil including a base portion having a central axis defining a base portion right side on a right side of the central axis and a base portion left side on a left side of the central axis, multiple right side stimulating elements in said base portion right side, said multiple right side stimulating elements substantially parallel to one another and configured to carry electrical current in substantially a first direction, multiple left side stimulating elements in said base portion left side, said multiple left side stimulating elements substantially parallel to one another and configured to carry electrical current in substantially the first direction, and a return portion having multiple right side return elements positioned on the right side of central axis, wherein each of the right side return elements corresponds to one of the multiple right side stimulating elements, and wherein each of the right side return elements is positioned further away from the central axis than its corresponding right side stimulating element, wherein each of the multiple right side return elements is configured to carry electrical current in substantially a second direction, wherein the second direction is an opposite direction to the first direction, the return portion further including multiple left side return elements positioned on the left side of the central axis, wherein each of the left side return elements corresponds to one of the multiple left side stimulating elements, and wherein each of the left side return elements is positioned further away from the central axis than its corresponding left side stimulating element, wherein each of the multiple left side return elements is configured to carry electrical current in substantially the second direction; and

activating said coil to stimulate a deep region of said subject'"'"'s brain.

20. The method of claim 19, wherein said neurophysiological condition is at least one of:

depression, bipolar disorder, schizophrenia, PTSD, Parkinson'"'"'s disease, Altzheimer'"'"'s disease, mild cognitive impairment, autism, Asperger'"'"'s syndrome, multiple sclerosis, ALS, Tourette'"'"'s syndrome, blepharospasm, stroke, chronic pain, eating disorder, obesity, anorexia nervosa, bulimia, any addiction including smoking addiction, drug addiction, alcoholism or gambling, ADHD, OCD, epilepsy, migraine, tinnitus.