Method and apparatus for producing a stabilized antimicrobial non-toxic electrolyzed saline solution exhibiting potential as a therapeutic
First Claim
1. An apparatus for producing a stable, non-toxic, antimicrobial electrolyzed saline solution exhibiting anti-infective and immune-enhancing potential as a therapeutic containing regulated amounts of stable reactive oxygen species (ROS), comprising:
- a) a container filled with a saline solution having a saline concentration of at least about 0.15%, the container comprising a single exterior opening that is fitted with a lid;
b) an inert anode and a spaced apart corresponding inert cathode placed within the saline solution;
c) a combination heating/cooling device disposed coaxially along an interior side of the container configured to exchange heat with the saline solution to maintain the saline solution at a desired temperature between 30°
F. and 100°
F. to prevent production of chlorates and to regulate relative concentrations of resulting components during electrolysis;
d) an exteriorly mounted circulation tube in fluid communication with a top and a bottom interior of the container configured with a pump to provide fluid circulation within the container to ensure complete mixing and electrolysis of the saline solution and a variation of less than 5% from batch to batch; and
e) a power source associated with the anode and cathode to apply an effective voltage potential less than about thirty volts between the cathode and the anode sufficient to produce a balanced mixture comprising one or more of Hypochlorous acid (HOCl), Hypochlorites (OCl−
, NaClO), dissolved Oxygen (O2), Chlorine (Cl2) between 1 to 200 ppm, Hydrogen (H2) gas, Hydrogen Peroxide (H2O2), Hydrogen ions (H+), Hypochloride (ClO), Superoxides (*O2−
, HO2), Ozone (O3) between about 1 ppm and about 50 ppm, Activated Hydrogen ions (H−
), Chloride ions (Cl−
), Hydroxides (NaOH, OH−
), Singlet Oxygen (*O2), *OCl, and *HO−
, and wherein total ROS is between about 0.05 ppm and about 50 ppm, utilizing at least one of electron and proton donation, ion and dissolved-gas transport, the temperature, anode and cathode spacing, saline solution circulation rate, and effective voltage combination selected to achieve desired electrolysis efficiencies and stable specie compositions containing stable ROS compounds while preventing production of chlorates.
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Accused Products
Abstract
An improved method and apparatus for producing a stable, non-toxic, antimicrobial electrolyzed saline solution with a broad range of anti-infective and therapeutic applications. The resulting electrolyzed saline solution exhibits a marked lack of toxicity upon intravenous, aspired, oral or topical application in mammals for therapeutic applications providing a broad platform, including topical disinfection, antimicrobial application, wound treatment, oxidative stress reduction and enhancement of immune function to better detect malfunctioning cells.
95 Citations
18 Claims
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1. An apparatus for producing a stable, non-toxic, antimicrobial electrolyzed saline solution exhibiting anti-infective and immune-enhancing potential as a therapeutic containing regulated amounts of stable reactive oxygen species (ROS), comprising:
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a) a container filled with a saline solution having a saline concentration of at least about 0.15%, the container comprising a single exterior opening that is fitted with a lid; b) an inert anode and a spaced apart corresponding inert cathode placed within the saline solution; c) a combination heating/cooling device disposed coaxially along an interior side of the container configured to exchange heat with the saline solution to maintain the saline solution at a desired temperature between 30°
F. and 100°
F. to prevent production of chlorates and to regulate relative concentrations of resulting components during electrolysis;d) an exteriorly mounted circulation tube in fluid communication with a top and a bottom interior of the container configured with a pump to provide fluid circulation within the container to ensure complete mixing and electrolysis of the saline solution and a variation of less than 5% from batch to batch; and e) a power source associated with the anode and cathode to apply an effective voltage potential less than about thirty volts between the cathode and the anode sufficient to produce a balanced mixture comprising one or more of Hypochlorous acid (HOCl), Hypochlorites (OCl−
, NaClO), dissolved Oxygen (O2), Chlorine (Cl2) between 1 to 200 ppm, Hydrogen (H2) gas, Hydrogen Peroxide (H2O2), Hydrogen ions (H+), Hypochloride (ClO), Superoxides (*O2−
, HO2), Ozone (O3) between about 1 ppm and about 50 ppm, Activated Hydrogen ions (H−
), Chloride ions (Cl−
), Hydroxides (NaOH, OH−
), Singlet Oxygen (*O2), *OCl, and *HO−
, and wherein total ROS is between about 0.05 ppm and about 50 ppm, utilizing at least one of electron and proton donation, ion and dissolved-gas transport, the temperature, anode and cathode spacing, saline solution circulation rate, and effective voltage combination selected to achieve desired electrolysis efficiencies and stable specie compositions containing stable ROS compounds while preventing production of chlorates. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An apparatus for producing a stable electrolyzed saline solution for treating a human or warm-blooded animal, comprising:
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a) a container filled with a saline solution having a concentration between about 0.15% and about 1.0% by weight, the container comprising a single exterior opening that is fitted with a lid; b) a permeable inert anode and a permeable inert cathode placed within the container associated with a power source configured to apply an effective voltage potential less than about thirty volts between the cathode and the anode to electrolyze the saline solution and produce a first target mixture of chemically reduced and oxidized molecules; c) a combination heating/cooling device disposed coaxially along an interior side of the container configured to exchange heat with the saline solution to maintain the saline solution at a desired temperature between 30°
F. and 100°
F. during electrolysis to prevent production of chlorates and to regulate relative concentrations of resulting components during electrolysis; andd) two exteriorly mounted circulation tubes, each circulation tube in fluid communication with a top and a bottom interior of the container and configured with a pump to provide fluid circulation within the container, wherein the structure and flow pattern of the two exteriorly mounted circulation tubes ensure complete mixing and electrolysis of the saline solution to produce ROS concentrations between about 0.05 ppm and 50 ppm with a variation of less than 5% from batch to batch, wherein the first target mixture is configured to mirror a second target mixture of chemically reduced and oxidized molecules, the second target mixture corresponding to a biological system. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification