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Mixing of fluids in fluidic systems

  • US 9,255,866 B2
  • Filed: 07/30/2014
  • Issued: 02/09/2016
  • Est. Priority Date: 03/13/2013
  • Status: Active Grant
First Claim
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1. A method, comprising:

  • flowing in a channel a series of fluid plugs comprising a first fluid plug comprising a first fluid, a second fluid plug comprising a second fluid, and a third fluid plug comprising a third fluid, wherein the first fluid plug has a first volume,wherein the second fluid plug is positioned between the first and third fluid plugs, andwherein the second fluid is immiscible with each of the first and third fluids,wherein prior to the flowing step, the channel comprises a reagent that is dry, the method comprising;

    contacting the first and/or third fluid with the reagent;

    while the first fluid plug is flowing, depositing at least a portion of the first fluid on a wall of the channel for combining with the third fluid plug;

    reducing the first volume of the first fluid plug by at least 50%;

    combining at least a portion of the first fluid into the third fluid plug so as to mix at least portions of the first and third fluids; and

    after the combining step, flowing in the channel the first fluid plug, the second fluid plug, and the third fluid plug which comprises the third fluid and at least a portion of the first fluid.

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