Biological optical measurement instrument and operation method therefor

• US 9,259,176 B2
• Filed: 11/02/2011
• Issued: 02/16/2016
• Est. Priority Date: 11/16/2010
• Status: Expired due to Fees

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi Medical Corporation (Hitachi, Ltd.)
• Inventors: Suzuki, Hiromichi
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/880,744
• Publication Number:
  US 20130211218A1
• Time in Patent Office: 1,567 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 2560/0437 Trolley or cart-type apparatus
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01J 3/28 Investigating the spectrum using colour filters G01J3/51
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01N 2021/3133 with selection of wavelengths before the sample
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 2021/3155 Measuring in two spectral ranges, e.g. UV and visible
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A biological optical measurement instrument includes a single temperature sensor that detects a radiation temperature from a plurality of light emitting elements that emit light of a predetermined wavelength, and an absorption coefficient correcting unit that corrects an absorption coefficient value of a notable substance inside the object on the basis of the radiation temperature detected by the temperature sensor, referring to data indicating a correspondence relationship between a temperature obtained in advance for each emitted light of the plurality of light emitting elements and an absorption coefficient value that varies according to the temperature.

Claims

1. A biological optical measurement instrument comprising:

a plurality of light emitting elements that emit light of a predetermined wavelength;

a single temperature sensor that detects an exhaust temperature exhausted from a casing accommodating the plurality of light emitting elements;

a light guide configured to guide the light of the plurality of light emitting elements to an object for irradiation;

a controller configured to receive a setting for an oscillation wavelength of light that is emitted by the plurality of light emitting elements;

an optical detector configured to measure a transmitted light intensity in a plurality of measurement points of the object;

a memory that stores

a first relation that indicates a correspondence relationship between the exhaust temperature detected by the single temperature sensor and a temperature of each of the plurality of light emitting elements,

a second relation that indicates a correspondence relationship between the temperature of each of the plurality of light emitting elements and the oscillation wavelength, and

a third relation that indicates a correspondence relationship between the oscillation wavelength and an absorption coefficient value of a notable substance inside the object; and

a processor configured to

(a) calculate the temperature of each of the plurality of light emitting elements based on the exhaust temperature detected by the temperature censor and the first relation,

(b) calculate the oscillation wavelength for each of the plurality of light emitting elements based on the temperature of each of the plurality of light emitting elements calculated by step (a) and the second relation, and

(c) calculate the absorption coefficient value of the oscillation wavelength calculated by step (b) to the notable substance inside the object based on the oscillation wavelength and the third relation.

2. The biological optical measurement instrument according to claim 1, further comprising:

an alarm configured to generate an alarm in a case where a parameter varies more greatly than a predetermined variation width during measurement of the transmitted light intensity by the optical detector.

3. The biological optical measurement instrument according to claim 2,

wherein the parameter is the exhaust temperature detected by the temperature sensor.

4. The biological optical measurement instrument according to claim 2,

wherein the parameter is the absorption coefficient value.

5. The biological optical measurement instrument according to claim 1, further comprising:

an alarm configured to generate an alarm in a case where any one of the oscillation wavelengths of the plurality of light emitting elements varies more greatly than a predetermined variation width during measurement of the transmitted light intensity by the optical detector.

6. The biological optical measurement instrument according to claim 1, wherein:

the controller is configured to adjust an optical output of the plurality of light emitting elements so that the intensity of the light with which the object is irradiated by the light guide becomes a predetermined intensity,

the processor is configured to correct the absorption coefficient value corresponding to each of the plurality of light emitting elements according to the optical output, and

the processor is configured to calculate the absorption coefficient value corresponding to the optical output for each of the plurality of light emitting elements, referring to data indicating a correspondence relationship between an optical output calculated in advance for each of the plurality of light emitting elements and the absorption coefficient value that varies according to a wavelength variation due to an optical output change in the light emitting elements.

7. A method of operating a biological optical measurement instrument, comprising:

irradiating an object with light of a predetermined wavelength from a plurality of light emitting elements;

measuring a transmitted light intensity in a plurality of measurement points of the object;

detecting, with a single temperature sensor, an exhaust temperature exhausted from a casing accommodating the plurality of light emitting elements therein;

storing, via a memory,

a first relation that indicates a correspondence relationship between the exhaust temperature of the plurality of light emitting elements detected by the single temperature sensor and a temperature of each of the plurality of light emitting elements,

a second relation that indicates a correspondence relationship between the temperature of each of the plurality of light emitting elements and an oscillation wavelength of light that is emitted by the plurality of light emitting elements, and

a third relation that indicates a correspondence relationship between the oscillation wavelength and an absorption coefficient value of a notable substance inside the object; and

via a processor

(a) calculating the temperature of each of the plurality of light emitting elements based on the exhaust temperature detected by the single temperature sensor and the first relation,

(b) calculating the oscillation wavelength for each of the plurality of light emitting elements based temperature of each of the plurality of light emitting elements calculated by step (a) and the second relation, and

(b) calculating the absorption coefficient of the oscillation wavelength calculated by step (b) and the third relation.

8. The method according to claim 7, further comprising:

adjusting the optical output of the light emitting elements so that the intensity of the light with which the object is irradiated becomes a predetermined value,

wherein in a case where the optical output is adjusted, the absorption coefficient value corresponding to the optical output is corrected for each of the plurality of light emitting elements, referring to data indicating a correspondence relationship between an optical output calculated in advance for each of the plurality of light emitting elements and the absorption coefficient value that varies according to a wavelength variation due to an optical output change of the light emitting elements.