Methods and apparatus for treating pulmonary embolism

• US 9,259,237 B2
• Filed: 06/09/2014
• Issued: 02/16/2016
• Est. Priority Date: 07/12/2013
• Status: Active Grant

• Current Assignee: Inari Medical, Inc.
• Original Assignee: Inceptus Medical, Llc
• Inventors: Quick, Richard, Cox, Brian J., Lubock, Paul, Rosenbluth, Robert F.
• Primary Examiner(s): NGUYEN, TUAN VAN
• Application Number:
  US14/299,933
• Publication Number:
  US 20150018859A1
• Time in Patent Office: 617 Days
• Field of Search: 606/128
• US Class Current: 1/1
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/320008 Scrapers
• CPC Class Codes: A61F 2/0105 Open ended, i.e. legs gathered only at one side
• CPC Class Codes: A61F 2/011 Instruments for their placement or removal
• CPC Class Codes: A61F 2/012 Multiple filtering units
• CPC Class Codes: A61F 2002/016 made from wire-like elements

Abstract

A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The individual clot engagement members can have a first portion and a second portion extending from the first portion, and the first portions can have a proximal region attached to the support member. In the deployed state, the individual second portions can extend from the distal region of one of the first portions and project radially outwardly relative to the support member in a curve that has a proximally extending section which defines a proximally facing concave portion.

Claims

1. A method of treating an embolism that at least partially restricts blood flow through a vessel, the method comprising:

deploying an embolectomy device within the embolism, wherein—

the embolectomy device includes a first plurality of clot engagement members configured to deploy at a first location along the device and a second plurality of clot engagement members configured to deploy at a second location along the device proximal of the first location, and

the embolectomy device is deployed by withdrawing a delivery catheter such that—

a terminus of at least one of the clot engagement members of the first and/or second pluralities of clot engagement members penetrates through the clot material along an arcuate path that extends radially outward, then proximally with respect to the elongated shaft, and then curves radially inwardly, whereby the clot material is held by at least one of the clot engagement members of the first and/or second pluralities of clot engagement members, and

at least one of the first plurality of clot engagement members penetrates through the clot material at the first location and, upon further withdrawal of the delivery catheter, at least one of the second plurality of clot engagement members penetrates through the clot material at the second location;

moving the embolectomy device and at least a portion of the embolism along the vessel; and

withdrawing the embolectomy device and at least a portion of the embolism from the vessel.

2. The method of claim 1 wherein deploying the embolectomy device comprises expanding at least one clot engagement member of the first and/or second pluralities of clot engagement members into arcuate shapes, each having a concave portion facing proximally.

3. The method of claim 1 wherein withdrawing the embolectomy device comprises urging the portion of the embolism into a catheter while applying a vacuum through the catheter.

4. The method of claim 3 wherein the vacuum applied through the delivery catheter is synchronized with withdrawal of the embolectomy device into the delivery catheter.

5. The method of claim 1 wherein withdrawing the embolectomy device includes extracting at least some clot material and thereby increasing flow in the blood vessel where flow had been reduced by the presence of a thrombus.

6. The method of claim 1 further comprising treating a pulmonary embolism with the embolectomy device.

7. The method of claim 6 wherein each clot engagement member of the first and second pluralities of clot engagement members has a first portion and a second portion extending from the first portion, and wherein the first portion has a proximal region attached to a support member and a distal region, and wherein the first portion extends distally in a longitudinal direction from the proximal region to the distal region.

8. The method of claim 7 wherein the second portion further includes an end section curving radially inward from the proximally extending section.

9. The method of claim 6 wherein each clot engagement member of the first and second pluralities of clot engagement members has a proximal region that is fixed to a distal portion of the embolectomy device.

10. The method of claim 1 wherein each clot engagement member of the first and/or second pluralities of clot engagement members has a plurality of microfeatures configured to facilitate adhesion of thrombus.

11. The method of claim 1 wherein each clot engagement member of the first and/or second pluralities of clot engagement members is coated to promote adhesion of thrombus.

12. The method of claim 1 wherein each clot engagement member of the first and/or second pluralities of clot engagement members defines an arc length that is between about 200 degrees and 340 degrees.

13. The method of claim 1 wherein each clot engagement member of the first and/or second pluralities of clot engagement members has a non-circular cross-section and is fabricated from a tube.