4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections

• US 9,259,426 B2
• Filed: 07/20/2007
• Issued: 02/16/2016
• Est. Priority Date: 07/20/2006
• Status: Active Grant

• Current Assignee: Gilead Sciences Inc.
• Original Assignee: Gilead Sciences Inc.
• Inventors: Gao, Ling-Jie, De Jonghe, Steven Cesar Alfons, Watkins, William John, Chong, Lee Shun, Herdewijn, Piet Andr Maurits Maria
• Primary Examiner(s): Wang, Shengjun
• Application Number:
  US12/374,433
• Publication Number:
  US 20090285782A1
• Time in Patent Office: 3,133 Days
• Field of Search: 514/266.4, 514/266.1, 514/266.2
• US Class Current: 1/1
• CPC Class Codes: A61K 31/517 ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• CPC Class Codes: A61K 31/5375 1,4-Oxazines, e.g. morpholine
• CPC Class Codes: A61K 31/5377 not condensed and containing further heterocyclic rings, e.g. timolol
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: C07D 239/72 Quinazolines; Hydrogenated quinazolines
• CPC Class Codes: C07D 239/78 with hetero atoms directly attached in position 2
• CPC Class Codes: C07D 239/86 with hetero atoms directly attached in position 4
• CPC Class Codes: C07D 239/88 Oxygen atoms
• CPC Class Codes: C07D 239/94 Nitrogen atoms
• CPC Class Codes: C07D 239/95 with hetero atoms directly attached in positions 2 and 4
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 409/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond

Abstract

This invention provides quinazoline derivatives represented by the structural formula: (I); wherein: R₂ is hydrogen, NR′R″, C_1-7 alkyl, arylC_1-7 alkyl or C_3-10 cycloalkyl; R₄ is amino, C_1-7 alkyl, C_2-7 alkenyl, C_3-10 cycloalkyl, C_3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted C_1-7 alkyl or C_3-10 cycloalkyl-C_1-7 alkyl; R₅ is hydrogen or C_1-7 alkyl, or R₅ and R₄ together with the nitrogen atom to which they are attached form a heterocyclic ring; Y is a single bond, C_1-7 alkylene, C_2-7 alkenylene or C_2-7 alkynylene; R₆ is halogen, heteroaryl or aryl; R′ and R″ are each independently hydrogen, C_1-7 alkyl-carbonyl or C_1-7 alkyl; provided that R₄ is not phenyl substituted with morpholino when R₂ is H and R₅ is H, and provided that when NR₄R₅ is piperazinyl, said NR₄R₅ is either non-substituted or substituted with methyl or acetyl; a pharmaceutically acceptable addition salt, a stereoisomer, a mono- or a di-N-oxide, a solvate or a pro-drug thereof, for the treatment of viral infections.

Claims

1. A method for treating an infection due to a virus from the Flaviridae family by administering to a patient in need thereof an effective amount of a quinazoline derivative according to the structural formula (I)

2. A method according to claim 1, wherein said virus belongs to a genus selected from the group consisting of Genus Flavivirus, Genus Hepacivirus and Genus Pestivirus.

3. A method according to claim 1, wherein said virus is hepatitis C virus.

4. A method according to claim 1, wherein Y is a bond, and R₆ is selected from the group consisting of 3,4-dimethoxyphenyl, 4-acetamidophenyl, 4-chlorophenyl and 4-fluorophenyl.

5. A method according to claim 1, wherein said at least one quinazoline derivative is administered together with one or more other antiviral drugs.

6. A method according to claim 5, wherein said other antiviral drug is selected from the group consisting of interferon alpha, ribavirin, NS3 protease inhibitors, and nucleoside- or non-nucleoside-based inhibitors of NS5B polymerase.

8. The method of claim 1, wherein R₂ is NH₂.

7. A method for treating an infection due to a virus from the Flaviridae family by administering to a patient in need thereof an effective amount of a quinazoline derivative selected from the group consisting of:

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-morpholino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-acetylpiperazino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-cyclohexylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-methylpiperazino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-piperidino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-hydrazino-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-butylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopentylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopropylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-isopentylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-propylamino)-quinazoline,

2-amino-6-(3,4-dimethoxyphenyl)-4-amino-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-morpholino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-acetylpiperazino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-cyclohexylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-methylpiperazino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-piperidino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-hydrazino-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-butylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-cyclopentylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-cyclopropylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-isopentylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-(N-propylamino)-quinazoline,

2-amino-6-(4-acetamidophenyl)-4-amino-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-morpholino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-amino-6-(4-chlorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-amino-6-(4-chlorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-acetylpiperazino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-cyclohexylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-methylpiperazino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-piperidino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-amino-6-(4-chlorophenyl)-4-hydrazino-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-butylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-cyclopentylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-cyclopropylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-isopentylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-(N-propylamino)-quinazoline,

2-amino-6-(4-chlorophenyl)-4-amino-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-morpholino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-amino-6-(4-fluorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-amino-6-(4-fluorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-acetylpiperazino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-cyclohexylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-methylpiperazino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-piperidino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-amino-6-(4-fluorophenyl)-4-hydrazino-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-butylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-cyclopentylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-cyclopropylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-isopentylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-(N-propylamino)-quinazoline,

2-amino-6-(4-fluorophenyl)-4-amino-quinazoline,

2-amino-6-bromo-4-(N-morpholino)-quinazoline,

2-amino-6-bromo-4-[N-(3-bromo)-anilino)]-quinazoline,

2-amino-6-bromo-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-amino-6-bromo-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-amino-6-bromo-4-(N-acetylpiperazino)-quinazoline,

2-amino-6-bromo-4-(N-cyclohexylamino)-quinazoline,

2-amino-6-bromo-4-(N-methylpiperazino)-quinazoline,

2-amino-6-bromo-4-(N-piperidino)-quinazoline,

2-amino-6-bromo-4-[N-(3-methyl)-anilino]-quinazoline,

2-amino-6-bromo-4-hydrazino-quinazoline,

2-amino-6-bromo-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-bromo-4-(N,N-dimethylamino)-quinazoline,

2-amino-6-bromo-4-(N-butylamino)-quinazoline,

2-amino-6-bromo-4-(N-cyclopentylamino)-quinazoline,

2-amino-6-bromo-4-(N-cyclopropylamino)-quinazoline,

2-amino-6-bromo-4-(N-isopentylamino)-quinazoline,

2-amino-6-bromo-4-(N-propylamino)-quinazoline,

2-amino-6-bromo-4-amino-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-morpholino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-acetylpiperazino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-cyclohexylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-methylpiperazino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-piperidino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-hydrazino-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-butylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopentylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopropylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-isopentylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-propylamino)-quinazoline,

2-acetamino-6-(3,4-dimethoxyphenyl)-4-amino-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-morpholino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-acetylpiperazino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-cyclohexylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-methylpiperazino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-piperidino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-hydrazino-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-butylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-cyclopentylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-cyclopropylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-isopentylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-(N-propylamino)-quinazoline,

2-acetamino-6-(4-acetamidophenyl)-4-amino-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-morpholino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-acetylpiperazino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-cyclohexylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-methylpiperazino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-piperidino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-hydrazino-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-butylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-cyclopentylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-cyclopropylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-isopentylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-(N-propylamino)-quinazoline,

2-acetamino-6-(4-chlorophenyl)-4-amino-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-morpholino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-acetylpiperazino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-cyclohexylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-methylpiperazino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-piperidino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-hydrazino-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-butylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-cyclopentylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-cyclopropylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-isopentylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-(N-propylamino)-quinazoline,

2-acetamino-6-(4-fluorophenyl)-4-amino-quinazoline,

2-acetamino-6-bromo-4-(N-morpholino)-quinazoline,

2-acetamino-6-bromo-4-[N-(3-bromo)-anilino)]-quinazoline,

2-acetamino-6-bromo-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,

2-acetamino-6-bromo-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,

2-acetamino-6-bromo-4-(N-acetylpiperazino)-quinazoline,

2-acetamino-6-bromo-4-(N-cyclohexylamino)-quinazoline,

2-acetamino-6-bromo-4-(N-methylpiperazino)-quinazoline,

2-acetamino-6-bromo-4-(N-piperidino)-quinazoline,

2-acetamino-6-bromo-4-[N-(3-methyl)-anilino]-quinazoline,

2-acetamino-6-bromo-4-hydrazino-quinazoline,

2-acetamino-6-bromo-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-bromo-4-(N,N-dimethylamino)-quinazoline,

2-acetamino-6-bromo-4-(N-butylamino)-quinazoline,

2-acetamino-6-bromo-4-(N-cyclopentylamino)-quinazoline,

2-acetamino-6-bromo-4-(N-cyclopropylamino)-quinazoline,

2-acetamino-6-bromo-4-(N-isopentylamino)-quinazoline,

2-acetamino-6-bromo-4-(N-propylamino)-quinazoline,

2-acetamino-6-bromo-4-amino-quinazoline,

6-bromo-N4-(2-methoxy-ethyl)-quinazoline-2,4-diamine,

4-((3-bromo)-anilino)-6-(4-(4′

-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-amino-2-methyl phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-amino-2-methyl phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-biphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-n-butyl phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-isobutylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-cyanophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-cyanophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-cyanophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyl)-quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-formylaminophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-formylaminophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-formylaminophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-formylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-formylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-formylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-isopropylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-morpholinophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-nitrophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-nitrophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-nitrophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-phenoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-piperazinylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-succinamidophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-succinamidophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(sulfamoylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-tert-butylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-vinylphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-(2-hydroxyethoxyphenyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(naphth-1-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(naphth-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4′

-benzoyl[1,1′

-biphenyl]-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-biphenylyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(oxoindan-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(benzodioxolyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-benzothien-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-bromothien-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-formyl-2-furyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-formylthien-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(furan-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(isoquinolin-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-methylindol-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-methylthien-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-methylthien-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(pyridin-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(4-phenoxathiinyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(quinolin-8-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(quinolin-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,

4-((3-bromo)-anilino)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(4′

-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-amino-2-methyl phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(5-amino-2-methyl phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-biphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-n-butyl phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-isobutylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-cyanophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-cyanophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-cyanophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-hydrazino-6-(4-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-hydrazino-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyl)-quinazolin-2-ylamine,

4-hydrazino-6-(4-formylaminophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-formylaminophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-formylaminophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-formylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-formylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-formylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-isopropylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-morpholinophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-nitrophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-nitrophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-nitrophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-phenoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-piperazinylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-succinamidophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-succinamidophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(sulfamoylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-tert-butylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-vinylphenyl)quinazolin-2-ylamine,

4-hydrazino-6-(4-(2-hydroxyhydrazino)phenyl)quinazolin-2-ylamine,

4-hydrazino-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(naphth-1-yl)quinazolin-2-ylamine,

4-hydrazino-6-(naphth-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(4′

-benzoyl[1,1′

-biphenyl]-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-biphenylyl)quinazolin-2-ylamine,

4-hydrazino-6-(oxoindan-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(benzodioxolyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-benzothien-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-bromothien-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,

4-hydrazino-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,

4-hydrazino-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,

4-hydrazino-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-hydrazinopyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-formyl-2-furyl)quinazolin-2-ylamine,

4-hydrazino-6-(5-formylthien-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(furan-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(isoquinolin-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-methylindol-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,

4-hydrazino-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(4-methylthien-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-methylthien-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(pyridin-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(4-phenoxathiinyl)quinazolin-2-ylamine,

4-hydrazino-6-(quinolin-8-yl)quinazolin-2-ylamine,

4-hydrazino-6-(quinolin-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,

4-hydrazino-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,

4-hydrazino-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(4′

-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-amino-2-methyl phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-amino-2-methyl phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-biphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-n-butyl phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-isobutylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-cyanophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-cyanophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-cyanophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyh-quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-formylaminophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-formylaminophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-formylaminophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-formylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-formylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-formylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-isopropylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-morpholinophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-nitrophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-nitrophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-nitrophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-phenoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-piperazinylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-succinamidophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-succinamidophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(sulfamoylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-tert-butylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-vinylphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-(2-hydroxyethoxyphenyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(naphth-1-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(naphth-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4′

-benzoyl[1,1′

-biphenyl]-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-biphenylyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(oxoindan-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(benzodioxolyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-benzothien-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-bromothien-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-[4-(4-chlorophenylsulfonyhpiperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-formyl-2-furyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-formylthien-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(furan-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(isoquinolin-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-methylindol-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-methylthien-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-methylthien-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(pyridin-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(4-phenoxathiinyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(quinolin-8-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(quinolin-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,

4-(N-cyclohexylamino)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(4′

-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-amino-2-methylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-amino-2-methylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-biphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-n-butyl phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-isobutylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-cyanophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-cyanophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-cyanophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-[(N′

,N′

-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(3-ethoxycarbonylpipericlino)carboxamidophenyl)-quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-formylaminophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-formylaminophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formylaminophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-formylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-formylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-isopropylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-morpholinophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-nitrophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-nitrophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-nitrophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-phenoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-piperazinylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-succinamidophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-succinamidophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(sulfamoylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-tert-butylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-vinylphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(2-hydroxyethoxyphenyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(naphth-1-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(naphth-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4′

-benzoyl[1,1′

-biphenyl]-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-biphenylyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(oxoindan-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(benzodioxolyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-benzothien-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-bromothien-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylam ine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-formyl-2-furyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-formylthien-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(furan-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(isoquinolin-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-methylindol-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-methylthien-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylthien-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(pyridin-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(4-phenoxathiinyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(quinolin-8-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(quinolin-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,

4-(N-(4-methyl)-piperazin-1-yl)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,

and/or a pharmaceutically acceptable addition salt thereof and/or a stereo-isomer thereof and/or a mono- or a di-N-oxide thereof.