Method of treating an ocular pathology by applying ultrasound to the trabecular meshwork and device thereof

• US 9,259,597 B2
• Filed: 08/26/2009
• Issued: 02/16/2016
• Est. Priority Date: 02/19/2008
• Status: Active Grant

• Current Assignee: Institut National De La Sante Et De La Recherche Medicale (Inserm) (Allianz Global Investors GmbH), Eye Tech Care SA
• Original Assignee: Institut National De La Sante Et De La Recherche Medicale (Inserm) (Allianz Global Investors GmbH), Eye Tech Care SA
• Inventors: Romano, Fabrizio, Chapuis, Philippe, Farcy, Laurent, Charrel, Thomas
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): NGUYEN, HIEN NGOC
• Application Number:
  US13/202,084
• Publication Number:
  US 20110301507A1
• Time in Patent Office: 2,365 Days
• Field of Search: 601/2
• US Class Current: 1/1
• CPC Class Codes: A61F 9/00745 using mechanical vibrations, e.g. ultrasonic
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61N 2007/0056 Beam shaping elements
• CPC Class Codes: A61N 2007/006 Lenses
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/027 with multiple foci created simultaneously
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A phacoemulsificator for the removal of lens tissue, wherein the phacoemulsificator contains:

• • a power source configured to provide pulsed electrical power, and
  • a pump configured to provide vacuum, characterized in that the phacoemulsificator contains at least one eye ring connectable to the pump wherein the proximal end of said eye ring is suitable to be applied onto an ocular globe and means to generate ultrasound beam connectable to the power source wherein said means are fixed on the distal end of the eye ring.

Claims

1. A method of treating glaucoma by generating ultrasound onto at least one eye'"'"'s area wherein the method comprises at least the following:

connecting an eye ring to a pump to provide vacuum,

connecting a generator for generating ultrasound beam to a power source to provide pulsed electrical power, and to generate a sine-wave signal in a range of 1 kHz to 25 MHz,

positioning the eye ring and the generator onto the eye for directing ultrasound onto at least one annular segment,

generating ultrasound energy onto said segment to treat at least one annular segment corresponding to at least one segment of a trabecular meshwork of the eye,

wherein the procedure to treat only glaucoma takes place in a single step; and

wherein the entire circumference of the eye is treated in one step.

2. The method according to claim 1 wherein the ultrasound energy is generated onto at least one annular segment corresponding to at least one segment of the trabecular meshwork of the eye.

3. A method according to claim 1 further comprising implementing a cataract surgery after having treated said annular segment.

4. A method according to claim 1 wherein the entire circumference of the eye is treated in one step.

5. A method according to claim 1 wherein the ultrasound energy comprises scattered ultrasound beam.

6. A method according to claim 1 wherein the eye ring comprises a sawn-off cone element open at both ends wherein a small base is the proximal end and the large base is the distal end, and

wherein the proximal end of the sawn-off cone element comprises an external annular flange,

wherein the external annular flange is applied onto the eye globe.

7. A method according to claim 6 wherein the annular flange is applied at approximately 2 mm of the limbus.

8. A method according to claim 1,

wherein the eye ring comprises a sawn-off cone element open at both ends wherein a small base is the proximal end and the large base is the distal end,

wherein the proximal edge of the sawn-off cone element comprises an annular groove communicating with at least one hose formed in the sawn-off cone element and connected to the pump and

wherein the sawn-off cone element is applied onto the eye and the pump is operated, the depression into the annular groove provide a deformation of the conjunctiva of the eye, said deformation forming an o-ring in the annular groove.

9. A method according to claim 8, wherein the sawn-off cone element is then closely interlinked in such a manner that said sawn-off cone element follows the micro movements of the eye during the whole treatment time.

10. A method according to claim 8, wherein the sawn-off cone is filled with an ultrasound coupling agent, the o-ring ensuring the sealing, the ultrasound coupling agent providing a cooling of the eye during the generation of ultrasound beam and an ultrasound coupling media that permits the propagation of ultrasound to the trabecular meshwork.

11. A method according to claim 8, wherein the frequency and/or the power and/or the duration of each pulse are selected or predetermined to produce a vibration of the trabecular meshwork over the whole or a part of the circumference.