Device and method for enhanced collection and assay of chemicals with high surface area ceramic

• US 9,259,708 B2
• Filed: 07/11/2012
• Issued: 02/16/2016
• Est. Priority Date: 07/11/2012
• Status: Active Grant

• Current Assignee: Battelle Memorial Institute
• Original Assignee: Battelle Memorial Institute
• Inventors: Addleman, Raymond S., Li, Xiaohong Shari, Chouyyok, Wilaiwan, Cinson, Anthony D., Bays, John T., Wallace, Krys
• Primary Examiner(s): HIXSON, CHRISTOPHER
• Application Number:
  US13/546,948
• Publication Number:
  US 20140017805A1
• Time in Patent Office: 1,315 Days
• US Class Current: 1/1
• CPC Class Codes: B01J 20/103 comprising silica
• CPC Class Codes: B01J 20/2803 Sorbents comprising a binder, e.g. for forming aggregated, agglomerated or granulated products
• CPC Class Codes: B01J 20/28042 Shaped bodies; Monolithic structures
• CPC Class Codes: B01J 20/28054 characterised by their surface properties or porosity
• CPC Class Codes: B01J 20/283 based on silica
• CPC Class Codes: B01J 20/3042 Use of binding agents; addition of materials ameliorating the mechanical properties of the produced sorbent
• CPC Class Codes: B01J 20/3078 Thermal treatment, e.g. calcining or pyrolizing
• CPC Class Codes: B01J 20/3234 Inorganic material layers
• CPC Class Codes: B01J 20/3293 Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
• CPC Class Codes: B01J 20/3295 Coatings made of particles, nanoparticles, fibers, nanofibers
• CPC Class Codes: Y10T 436/255 including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

A method and device for enhanced capture of target analytes is disclosed. This invention relates to collection of chemicals for separations and analysis. More specifically, this invention relates to a solid phase microextraction (SPME) device having better capability for chemical collection and analysis. This includes better physical stability, capacity for chemical collection, flexible surface chemistry and high affinity for target analyte.

Claims

1. A device for enhanced capture of target analytes, comprising:

a. a support surface; and

b. a thin film containing a mixture of at least two nanomaterials bound to the support surface, the mixture of the at least two nanomaterials including a first plurality of nanoporous particles, and a second plurality of nanoparticles as a binder to the nanoporous particles and the support surface, wherein the nanomaterials include a polyfunctional chemistry installed therein for capture of a target analyte.

2. The device of claim 1 wherein the nanoporous particles are silica nanoporous particles.

3. The device of claim 1 wherein the support surface is a substrate.

4. The device of claim 3 wherein the substrate is one of the following:

a fiber, a metal wire, a planar support, and a tubular structure.

5. The device of claim 1 wherein the support surface is porous.

6. The device of claim 1 wherein support surface is coated by the thin film containing the mixtures of the nanoporous particles and the nanoparticles.

7. The device of claim 1 wherein the thin film is coated on the outside of the support surface.

8. The device of claim 1 wherein the thin film is coated on the inside of the support surface.

9. The device of claim 1 wherein the polyfunctional chemistry forms a sorbent layer.

10. The device of claim 9 wherein the sorbent layer is a silane, and other surface chemistries are installed such as physisorbed low vapor pressure organics or covalently bound surface chemistries such as phosphonic acid with organic components.

11. The device of claim 9 wherein the sorbent layer comprises the polyfunctional chemistry, wherein the polyfunctional chemistry is at least one of the following:

organics, organometallics, metals, nanoparticle, complex molecules, and combinations thereof.

12. The device of claim 1 wherein the target analyte is a gas-phase or a liquid-phase analyte.

13. The device of claim 12 wherein the gas or liquid-phase trace level analyte is at least one of the following:

explosives, explosive variants, chemical weapons agents, pesticides, and volatile organic compounds (VOCs).

31. The device of claim 1 wherein the thin film is calcined at less than approximately 550°

C.

14. A method of selective and specific capturing of target analytes comprising:

a. providing a support surface;

b. coating the support surface with a thin film containing a mixture of at least two nanomaterials bound to the support surface, the mixture of the at least two nanomaterials including a first plurality of nanoporous particles, and a second plurality of nanoparticles as a binder to the nanoporous particles and the support surface; and

c. installing polyfunctional chemistry on a surface of the thin film to capture target analytes.

15. The method of claim 14 wherein the nanoporous particles are silica nanoporous particles.

16. The method of claim 14 wherein the support surface is a substrate.

17. The method of claim 16 wherein the substrate is one of the following:

a fiber, a metal wire, a planar support, and a tubular structure.

18. The method of claim 14 wherein the thin film is coated on the outside of the support surface.

19. The method of claim 14 wherein the thin film is coated on the inside of the support surface.

20. The method of claim 14 wherein the thin film is deposited on to the support surface by at least one of the following:

dip coating, molding, and spray-on.

21. The method of claim 20 wherein the thin film is subsequently sintered to solidify film adhesion to the support surface.

22. The method of claim 14 wherein the support surface is porous.

23. The method of claim 14 wherein the polyfunctional chemistry forms a sorbent layer.

24. The method of claim 23 wherein the sorbent layer is a silane.

25. The method of claim 23 wherein the sorbent layer comprises the polyfunctional chemistry, wherein the polyfunctional chemistry is at least one of the following:

organics, metal centers, complex molecules, and combinations thereof.

26. The method of claim 14 wherein the target analyte is a gas-phase or a liquid-phase analyte.

27. The method of claim 26 wherein the gas or liquid-phase analyte is at least one of the following:

explosives, explosive variants, chemical weapons agents, pesticides, drug, or volatile organic compounds (VOCs).

32. The method of claim 14 further comprising calcining the thin film at less than approximately 550°

C.

28. A device for selective and specific capture of target analytes, comprising:

a. a tubular support having an empty space; and

b. a thin film containing a mixture of at least two nanomaterials including a first plurality of nanoporous particles, and a second plurality of nanoparticles as a binder to the nanoporous particles and the tubular support, the thin film coated inside the tubular support, wherein a surface of the nanoporous particles includes polyfunctional chemistry installed therein for selective and specific capture of a target analyte drawn into the empty space.

29. A method of selective and specific capture of target analytes comprising:

a. providing a tubular support having an empty space;

b. coating the inside of the tubular support with a thin film containing a mixture of a first plurality of nanoporous particles, and a second plurality of nanoparticles as a binder to the nanoporous particles and the tubular support;

c. installing polyfunctional chemistry on a surface of the nanoporous particles; and

d. drawing a target analyte into the empty space for specific capture of the analyte with the nanoporous particles containing the chemistry.

30. The method of claim 29 further comprising separating and analyzing the captured analytes.