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Modified human four helical bundle polypeptides and their uses

  • US 9,260,472 B2
  • Filed: 10/18/2007
  • Issued: 02/16/2016
  • Est. Priority Date: 02/02/2004
  • Status: Expired due to Fees
First Claim
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1. An isolated four helical bundle (4HB) polypeptide chosen from the group consisting of human growth hormone, interferon, erythropoietin, and granulocyte cell stimulating factor, comprising a ribosomally incorporated para-acetyl-phenylalanine within the C-D loop of the 4HB polypeptide, wherein the 4HB polypeptide with para-acetyl-phenylalanine has at least a 2-fold increased serum half-life over the wild type 4HB polypeptide.

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