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Methods and compositions for inhibiting CD32b expressing cells

  • US 9,260,523 B2
  • Filed: 11/21/2011
  • Issued: 02/16/2016
  • Est. Priority Date: 05/30/2007
  • Status: Active Grant
First Claim
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1. A method of activating at least one B cell or dendritic cell comprising contacting the cell with an immunoglobulin comprising an Fc region that binds Fcγ

  • RIIb on the cell surface with enhanced affinity as compared to a parent immunoglobulin and at least one Fv region that binds CD40 on the cell surface, wherein the immunoglobulin comprises Fc substitutions S267E and L328F as compared to a parent Fc region, wherein the numbering is according to the EU index, as in Kabat.

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