Methods and compositions for inhibiting CD32b expressing cells
First Claim
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1. A method of activating at least one B cell or dendritic cell comprising contacting the cell with an immunoglobulin comprising an Fc region that binds Fcγ
- RIIb on the cell surface with enhanced affinity as compared to a parent immunoglobulin and at least one Fv region that binds CD40 on the cell surface, wherein the immunoglobulin comprises Fc substitutions S267E and L328F as compared to a parent Fc region, wherein the numbering is according to the EU index, as in Kabat.
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Abstract
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell'"'"'s surface and an FcγRIIb on the cell'"'"'s surface, methods for their generation, and methods for using the immunoglobulins.
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1 Claim
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1. A method of activating at least one B cell or dendritic cell comprising contacting the cell with an immunoglobulin comprising an Fc region that binds Fcγ
- RIIb on the cell surface with enhanced affinity as compared to a parent immunoglobulin and at least one Fv region that binds CD40 on the cell surface, wherein the immunoglobulin comprises Fc substitutions S267E and L328F as compared to a parent Fc region, wherein the numbering is according to the EU index, as in Kabat.
Specification