Positioning device for a sample distribution apparatus, sample distribution apparatus with positioning device and method for positioning

• US 9,261,524 B2
• Filed: 01/26/2011
• Issued: 02/16/2016
• Est. Priority Date: 01/26/2010
• Status: Active Grant

• Current Assignee: Eppendorf AG
• Original Assignee: Eppendorf AG
• Inventors: Von Beichmann, Boris, Mellenthin, Uwe, Disselbach, Rainer
• Primary Examiner(s): LARKIN, DANIEL SEAN
• Application Number:
  US13/014,638
• Publication Number:
  US 20110209564A1
• Time in Patent Office: 1,847 Days
• Field of Search: 738/640.1, 738/642.3, 738/642.5
• US Class Current: 1/1
• CPC Class Codes: B01L 3/0217 of the plunger pump type medical syringes A61M
• CPC Class Codes: B01L 9/00 Supporting devices; Holding devices
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: B01L 9/54 Supports specially adapted for pipettes and burettes automated pipetting stations G01N35/10
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/1067 for transfer to or from containers having different spacing

Abstract

The invention relates to a positioning device for a sample distribution apparatus, such as a pipetting apparatus, providing a first part, at which a sample transport device can be arranged, a second part, at which a sample holder can be arranged, wherein the first part and the second part are arranged moveable in relation to each other between a first position and an adjusted target position of the first and second part for performing a positioning motion, such that a sample can be conveyed towards the sample holder by the positioning motion. The automated change of the target position assists for achieving an error-free positioning and sample distribution. A corresponding method for the automatical change of a position of a first part relative to a second part using the positioning device, is also claimed.

Claims

1. Positioning device (1;

1′

) for a sample distribution apparatus (100;

100′

, 200) providing;

a first part (10;

10′

), configured such that a sample transport device (102) is arranged at the first part,

a second part (20;

20′

), configured such that a sample holder (103;

103′

) is arranged at the second part,

wherein the first part and the second part are arranged moveable relative to each other between a first position and an adjusted target position of the first and the second part for performing a positioning motion,

wherein an actuation motion is provided, which serves the conveyance of the sample,

a positioning auxiliary device (30;

30′

),

which provides at least one means for limiting (40;

40′

) of the relative mobility of the first and the second part in the adjusted target position,

which provides at least one means for adjustment (50;

50′

) of the n-th target position from a plurality of N predetermined target positions as the adjusted target position,

which provides at least one means for changing (60;

60′

) of the adjusted target position from the n-th target position to a (n+1)-th target position, and

which provides at least one first means for coupling (70;

70′

) of the actuation motion and the at least one means for changing such that the change from said n-th target position to said (n+1)-th target position can be effected by the actuation motion via the at least one means for coupling,

wherein the positioning device is configured such that the n-th target position is adjusted, before the positioning motion of the first and the second part into the n-th target position is finished.

2. Positioning device according to claim 1, characterized in that the actuation motion is said positioning motion.

3. Positioning device according to claim 1, characterized in that the actuation motion is a motion, which is manually conducted by user.

4. Positioning device according to claim 1, characterized in that a plurality of N means for limiting are provided, by means of which N target positions can be adjusted.

5. Positioning device according to claim 1, characterized in that the positioning device provides a guiding device, by means of which a guided positioning motion of the first and the second part relative to each other between a first position and an n-th target position can be conducted.

6. Positioning device according to claim 5, characterized in that said guiding device is configured for performing a translatoric relative motion of the first and second part along a linear guiding direction, which runs substantially in parallel to said rotation axis such that the engagement of the engagement element into said guiding grooves of a drum device effects that the engagement element, which engages the guiding groove, rotates the drum device during said substantially translatoric positioning motion, whereby it is changed from the n-th target position to the (n+1)-th target position and the latter is adjusted to be a new adjusted target position.

7. Positioning device according to claim 1, characterized in that the at least one first means for coupling is mechanically such that it mechanically effects the change from said n-th target position to said (n+1)-th target position during the positioning motion.

8. Positioning device according to claim 1, characterized in that the at least one means for limiting, the at least one means for adjustment and the at least one means for changing are operating mechanically.

9. Positioning device according to claim 1, characterized in that the at least one means for limiting provide a plurality of N stopping areas, at which the motion of the first and second part in a motion direction is blocked by attachment of both parts, if they are guided from the first position in the direction of a target position.

10. Positioning device according to claim 9, characterized in that a counter stopping area is assigned to the positioning auxiliary device, the counter stopping area being arranged at the first part such that the relative motion of the first and the second part can be blocked by the attachment of an n-th stopping area at said counter stopping area.

11. Positioning device according to claim 10, characterized in that the positioning auxiliary device provides a means for a manual adjustment of the position of the counter stopping area in relation to the first part.

12. Positioning device according to claim 1, characterized in that the at least one means for coupling are moveably arranged at the first part and that the positioning auxiliary device provides also at least one second means for coupling the positioning motion to the at least one first means for coupling such that the at least one first means for coupling is moveable by the at least one second means for coupling during a positioning motion.

13. Positioning device according to claim 12, characterized in that the at least one second means for coupling is configured for moving an engagement element along an engagement direction, whereby the means include a slotted link device and a slide block member, whereby the slotted link device is arranged at the second part and is arranged extending substantially along a linear guiding direction and the slide block member being arranged substantially extending perpendicular to the engagement direction and substantially perpendicular to a rotational axis, arranged firmly to the engagement element.

14. Positioning device according to claim 13, characterized in that said slotted link device provides a slotted link and said slide block member provides a sliding block which can be guided through the slotted link, wherein the slotted link is shaped such that the engagement element does not engage into a guiding groove during the positioning motion from the first position to the n-th target position and does engage into a guiding groove during the positioning back motion from the n-th target position to the first position, whereby it is changed during the return path from the n-th target position to the (n+1)-th target position and the latter being adjusted as a new target position.

15. Positioning device according to claim 1, characterized in that in at least one means for adjusting are arranged at the second part and include a rotatable drum device, at which the at least one means for limiting and the at least one means for changing are arranged.

16. Positioning device according to claim 15, characterized in that the drum device provides a substantially cylinder-shaped exterior side and that the at least one means for changing provides a plurality of N helically-shaped guiding grooves, which coil up at said exterior side and are arranged equidistant, wherein the open ends of said guiding grooves are directed in the direction of the rotation axis of the drum device.

17. Positioning device according to claim 16, characterized in that the at least one first means for coupling comprises an engagement element, which is arranged at the first part, which is arranged moveable in a engagement direction perpendicular to a rotation axis at the first part, and is arranged unmovable in the direction of the rotation axis, and which is configured for engaging said guiding grooves.

18. Positioning device according to claim 1, characterized in that the first part is arranged moveable and that the second part is arranged unmovable at the sample distribution apparatus or that the first part is arranged unmovable at the sample distribution apparatus and the second part is arranged moveable.

19. Positioning device according to claim 1, characterized in that the first part can be manually moved in relation to the second part by a user.

20. Positioning device according to claim 1, characterized in that the positioning auxiliary device provides means for a manual adjustment of the n-th target position from a plurality of N predetermined target positions.

21. Positioning device according to claim 1, characterized in that the positioning device comprises spring means for the suspension of the relative motion of the first and second part, once the relative motion approaches the n-th target position.

22. Sample distribution apparatus with a positioning device according to claim 1, wherein the positioning device provides a first part, at which a holding device for holding of a sample transport device is arranged, provides a second part, which is moveably arranged in relation to the first part and at which a sample holder can be arranged, wherein the first part and the second part are moveably arranged in relation to each other between a first position and an adjusted target position of the first and second part for the performance of a positioning motion, and provides an inclination apparatus, by means of which the holding device for holding the sample transport device is arranged to be inclined against the first part.

23. Sample distribution apparatus according to claim 22, characterized in that third means for coupling of the positioning motion and said means for changing are provided such that a change of the height of the supply container holder is effected during the approaching of a starting position.

24. Sample distribution apparatus configured to be a pipetting apparatus, which provides a positioning device according to any one of claim 21.

25. Sample distribution apparatus according to claim 24, wherein the positioning device provides a first part, at which a sample transport device can be arranged, provides a second part, which is moveably arranged in relation to the first part and at which a sample holder can be arranged, wherein the first part and the second part are moveably arranged relative to each other between a first position and an adjusted target position for the performance of a positioning motion such that a sample is conveyable against the sample holder by the positioning motion between the first position and the adjusted target position and is conveyable at the target position by release from the sample transport device to the sample holder, wherein an actuation motion is provided, which serves the conveyance of the sample,

wherein the sample distribution apparatus further provides an automatic height adjustment device, at which a height adjustable component of the apparatus is automatically adjusted in height by the actuation motion.

26. Sample distribution apparatus according to claim 24, characterized in that the first part is configured for holding a sample transport device, which is a commercially available hand-operated pipette or a commercially available hand-operated dispenser.

27. Method for positioning a first part relative to a second part in subsequent steps at, respectively, different target positions by means of a sample distribution apparatus according to claim 24 comprising the steps, that an n-th positioning motion of the first and the second part relative to each other is performed between the first position and the predetermined n-th target position, the n-th target position being adjustable at the positioning device as one of N possible predetermined target positions, that a subsequent (n+1)-th positioning motion of the first and the second part relative to each other is performed between the first position and the (n+1)-th target position, by utilizing an actuation motion to effect the change from the n-th target position to the (n+1)-th target position by the coupling of the actuation motion with the positioning auxiliary device such that the (n+1)-th target position is adjusted as said new adjusted target position.

28. Method for positioning a first part relative to a second part in subsequent steps at, respectively, different target positions by means of a positioning device according to any one of claims 1 to 21, comprising the steps,

that an n-th positioning motion of the first and the second part relative to each other is performed between the first position and the predetermined n-th target position, the n-th target position being adjustable at the positioning device as one of N possible predetermined target positions,

that a subsequent (n+1)-th positioning motion of the first and the second part relative to each other is automatically performed between a first position and the (n+1)-th target position,

by utilizing an actuation motion to effect the change from the n-th target position to the (n+1)-th target position by the coupling of the actuation motion with the positioning auxiliary device such that the (n+1)-th target position is adjusted as said new adjusted target position.

29. Method according to claim 28, wherein the return path of the n-th positioning motion from said n-th target position back to the first position is utilized to effect said change from the n-th target position to the (n+1)-th target position by a coupling of the positioning back motion with the positioning auxiliary device such that the (n+1)-th target position is adjusted as said new adjusted target position.