Apparatus and method for measuring a tissue analyte such as bilirubin using the Brewster's angle

• US 9,265,457 B2
• Filed: 04/28/2011
• Issued: 02/23/2016
• Est. Priority Date: 06/03/2010
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Kudavelly, Srinivas Rao, Meijer, Eduard Johannes
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/701,052
• Publication Number:
  US 20130085351A1
• Time in Patent Office: 1,762 Days
• Field of Search: 600/310, 600/322, 600/315
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: G01N 2021/215 Brewster incidence arrangement
• CPC Class Codes: G01N 2021/3137 with selection of wavelengths after the sample
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 21/474 Details of optical heads therefor, e.g. using optical fibres

Abstract

A tissue analyte measuring device (2) includes a light source (4) structured to emit unpolarized light toward the skin surface of a subject, and a detector assembly (8) configured to receive light reflected from the skin surface of the subject and the transcutaneous tissues of the subject, the detector assembly including a polarizing filter (12) and a number of light detector subassemblies (14). The polarizing filter is structured to filter out s-polarized light and pass only p-polarized light to light detector subassemblies. The light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane of the measuring device, wherein the predetermined angle is an angle (the Brewster'"'"'s angle) at which only s-polarized light will be reflected by the skin surface when the unpolarized light is incident thereon.

Claims

1. A tissue analyte measuring device (2), comprising:

a light source (4) structured and positioned to emit unpolarized light toward a skin surface (6) of a subject at a predetermined angle at which only s-polarized light will be reflected by the skin surface when the measuring device is positioned adjacent to the skin surface;

a detector assembly (8) configured to receive light reflected from the subject including light reflected by the skin surface of the subject and by transcutaneous tissues of the subject, the detector assembly including a polarizing filter (12) and a number of light detector subassemblies (14), the polarizing filter being structured to filter out s-polarized light and pass only p-polarized light to the number of light detector subassemblies; and

one or more physical computer processors configured by computer readable instructions to control the light source and the detector assembly and to compute a measurement relating to the analyte from the measured p-polarized light.

2. The measuring device according to claim 1, wherein the light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at the predetermined angle with respect to a normal to a light emitting plane (7) of the measuring device, the light emitting plane being configured to be positioned adjacent to a skin surface of a subject.

3. The measuring device according to claim 2, wherein the predetermined angle is a Brewster'"'"'s angle determined using a refractive index of human skin.

4. The measuring device according to claim 2, wherein the light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device and be incident on the skin surface at a predetermined angle with respect to a normal to the skin surface when the measuring device is placed against the skin surface.

5. The measuring device according to claim 4, wherein the predetermined angle is a Brewster'"'"'s angle determined using a refractive index of human skin.

6. The measuring device according to claim 1, wherein a number of light detector assemblies is a plurality of light detector assemblies.

7. The measuring device according to claim 6, wherein each of the light detector subassemblies includes a filter (16) and a photodetector (18).

8. The measuring device according to claim 7, wherein each filter is centered at a predetermined wavelength.

9. The measuring device according to claim 8, wherein the tissue analyte is bilirubin, wherein the filters are structured to pass a plurality of predetermined wavelengths required for determining one or both of a TCB level and a TSB level of the subject.

10. The measuring device according to claim 9, wherein the one or more physical computer processors comprises a controller (20) operatively coupled to the light source and the number of light detector subassemblies, wherein each photodetector is structured to convert light received thereby to an electrical signal, and wherein the controller is adapted to determine one or both of a TCB level and a TSB level of the subject based on the electrical signal received from each photodetector.

11. The measuring device according to claim 7, wherein each photodetector is a photodiode.

12. A method of measuring a tissue analyte of a subject, the method being implemented in a computer system including one or more physical processors and storage media storing machine-readable instructions, the method comprising:

directing unpolarized light at a skin surface of a subject at a predetermined angle with respect to a normal to the skin surface, wherein in response to the unpolarized light being incident on the skin surface, reflected light is reflected by the skin surface, comprising only s-polarized light, and by transcutaneous tissues of the subject;

filtering out s-polarized light from the reflected light and passing only p-polarized light from the reflected light; and

determining a measurement relating to the analyte based on the p-polarized light.

13. The method according to claim 12, wherein the predetermined angle is an angle at which only s-polarized light will be reflected by the skin surface.

14. The method according to claim 12, wherein the predetermined angle is a Brewster'"'"'s angle determined using a refractive index of human skin.

15. The method according to claim 12, wherein the determining includes filtering the p-polarized light to produce one or more filtered lights, detecting the one or more filtered lights and determining the measurement using the detected one or more filtered lights.

16. The method according to claim 15, wherein the one or more filtered lights is a plurality of filtered lights each including a predetermined wavelength.

17. The method according to claim 16, wherein the tissue analyte is bilirubin, and wherein each predetermined wavelength is required for determining one or both of a TCB level and a TSB level of the subject.