Probes having deployable sites and methods for making the same

• US 9,265,465 B2
• Filed: 06/03/2012
• Issued: 02/23/2016
• Est. Priority Date: 06/04/2011
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Najafi, Khalil, Egert, Daniel
• Primary Examiner(s): Cohen, Lee S
• Assistant Examiner(s): Cardinal, Erin M
• Application Number:
  US13/487,234
• Publication Number:
  US 20120310067A1
• Time in Patent Office: 1,360 Days
• Field of Search: 600/372, 600/377, 600/378, 600/393
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/685 Microneedles
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0502 Skin piercing electrodes
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/0543 Retinal electrodes

Abstract

A probe for interfacing with biological tissue includes a shank. A site to receive a signal from or stimulate the biological tissue is deployably connected to the shank. An insulated interconnect is connected to the site to guide signals or a fluid between the site and the shank. An actuator displaces the site away from a protected position on the shank to a deployed position in the biological tissue to be monitored or stimulated by the site.

Claims

1. A probe for interfacing with biological tissue, comprising:

a shank having a leading edge defined on the shank, the leading edge to cut a path into the biological tissue and move the biological tissue aside during insertion of the probe into the biological tissue;

at least one site to monitor by receiving a signal from or to stimulate the biological tissue, the at least one site deployable from the shank;

at least one insulated interconnect connected to the at least one site, to guide electrical signals between the at least one site and the shank; and

at least one actuator to displace the at least one site away from a respective protected position defined by a recessed area defined along the shank and defined on the shank to a respective deployed position in the biological tissue to be monitored or stimulated by the at least one site.

2. The probe as defined in claim 1 wherein the deployed position in the biological tissue to be monitored is beyond scar tissue formed as an immune response to the probe, and wherein the deployed position is spaced at least about 50 μ

m from the protected position.

3. The probe as defined in claim 1 wherein the at least one site in the deployed position remains loosely connected to the probe so that the at least one site is floatable with the biological tissue.

4. The probe as defined in claim 1 wherein the deployed position is spaced at least about 1 μ

m from the protected position.

5. The probe as defined in claim 1 wherein the actuator is a mechanical spring.

6. The probe as defined in claim 5 wherein capillary action forces cause the actuator to retract the at least one site into the protected position upon exposure of the actuator to a wetting fluid.

7. The probe as defined in claim 5, further comprising a shrinking gel that causes the actuator to retract the at least one site into the protected position upon exposure of the actuator to a fluid including the gel and subsequent drying of the fluid.

8. The probe as defined in claim 5, further comprising a glue, wherein the actuator is releasably retained in the retracted position by the glue that is dissolvable in the biological tissue.

9. The probe as defined in claim 8 wherein the glue is chosen from sugar, agar gel, sugar saccharides, gelatin, or combinations thereof.

10. The probe as defined in claim 5 wherein the spring is bi-stable.

11. The probe as defined in claim 5 wherein the spring is retracted by forces on a tip during implantation and wherein the spring is automatically released when the implantation forces on the tip are removed.

12. The probe as defined in claim 5 wherein the spring is a balloon actuator retracted by pressure and actuated by stored elastic energy.

13. The probe as defined in claim 5 wherein the actuator is caused to retract the at least one site to the respective protected position by a retraction mechanism chosen from the group consisting of:

a common micro manipulator stage;

a forced convection fluid stream by direct impingement; and

a forced convection fluid stream by fluid motion-generated pressure differential.

14. The probe as defined in claim 1 wherein the actuator is passively triggered by a change of environment during or after implantation.

15. The probe as defined in claim 1 wherein the actuator is activated by a chemical reaction that changes an adhesive layer or by a chemical reaction wherein the chemical reaction is initiated by a change of pH, humidity, temperature or magnetic field strength.

16. The probe as defined in claim 1 wherein the actuator is integrated into the probe.

17. The probe as defined in claim 1 wherein the at least one site includes an electrode, a chemical sensor, or combinations thereof.

18. The probe as defined in claim 17 wherein the at least one site further includes an opening of an optical waveguide, a port for fluid flow, a structure for drug release, or combinations thereof.

19. The probe as defined in claim 1 wherein the at least one shank is a plurality of shanks arranged in an array insertable in the biological tissue as a single piece.

20. The probe as defined in claim 1 wherein the deployed position in the biological tissue to be monitored or stimulated is spaced from about 50 μ

m to about 150 μ

m from the protected position.