Method and system for improved estimation of time of left ventricular pacing with respect to intrinsic right ventricular activation in cardiac resynchronization therapy

• US 9,265,954 B2
• Filed: 07/26/2013
• Issued: 02/23/2016
• Est. Priority Date: 07/26/2013
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ghosh, Subham
• Primary Examiner(s): Dietrich, Joseph
• Application Number:
  US13/952,043
• Publication Number:
  US 20150032172A1
• Time in Patent Office: 942 Days
• Field of Search: 607/18
• US Class Current: 1/1
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A method and system of cardiac pacing is disclosed. A baseline rhythm is determined. The baseline rhythm includes a baseline atrial event and a baseline right ventricular RV event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of activation times determined from a plurality of body-surface electrodes. A determination is made as to whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times. A correction factor is applied to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the RV event is disparate from the earliest RV activation time. The processor is configured to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before RV sensing time.

Claims

1. A computer-implemented method of cardiac pacing comprising:

determining a baseline rhythm, the baseline rhythm includes a baseline atrial event and a baseline right ventricular (RV) event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of cardiac electrical activation times determined from a plurality of body-surface electrodes;

determining whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times;

applying a correction factor to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the time interval measured from the atrial event to the RV event is disparate from the time interval measured from the atrial event to the earliest RV activation time; and

configuring the processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before the RV sensing time.

2. The method of claim 1 wherein the atrial event is acquired from one of an implanted cardiac lead or a leadless device, the atrial event being sensed from an atrial pace or an intrinsic atrial event.

3. The method of claim 1 wherein the atrial event includes onset of a depolarization acquired through a surface ECG electrode.

4. The method of claim 1 wherein the correction factor is based on the difference between the RV event and the earliest RV activation time.

5. The method of claim 4 wherein the pre-excitation interval is a time-interval defined by electrical stimuli delivered to the left ventricle (LV) before sensing the RV event.

6. The method of claim 1 further comprising:

determining whether a RV lead is positioned in an area that is electrically late in activation.

7. The method of claim 6 wherein the electrically late area activates later than 40-60 ms after onset of depolarization.

8. The method of claim 6 wherein delivery of left ventricular pacing pulses is timed to occur 50-60 ms before RV event.

9. The method of claim 6 wherein delivery of left ventricular pacing pulses is timed to occur 40-70 ms before RV event.

10. The method of claim 1 wherein disparate is defined as the earliest RV activation time which is about 40-300 ms ahead of the earliest sensed RV event.

11. The method of claim 10 wherein the earliest RV activation time is defined by an earliest activation time on right-sided electrodes among a plurality of activation times measured from a plurality of ECG electrodes on the torso surface.

12. The method of claim 10 wherein the earliest RV activation time is defined by a timing of onset of a far-field RV electrogram measured from the device.

13. The method of claim 10 wherein each of the plurality of activation times are determined by a timing of a steepest negative slope on the unipolar ECG signal from each of a plurality of surface electrodes and a common fiducial point.

14. The method of claim 13 wherein the common fiducial point is the onset of depolarization (Q-point) measured from a surface ECG electrode or timing of an atrial event as sensed by an implantable medical device.

15. The method of claim 1 further comprising:

acquiring a plurality of signals from the plurality of body-surface electrodes;

generating a body surface potential map (BSPM) from the plurality of signals; and

displaying one or more BSPM on a graphical user interface.

16. The method of claim 1 further comprising:

determining an earliest body-surface activation time during RV only pacing at a short AV delay in a CRT patient and associating an electrode from the plurality of body-surface electrodes corresponding to the earliest activation in a RV only paced rhythm.

17. The method of claim 1 wherein determining the earliest body-surface activation time occurs post-implant.

18. The method of claim 1 further comprising:

acquiring a plurality of intrinsic rhythm signals from the plurality of body-surface electrodes;

generating an intrinsic rhythm body surface potential map (BSPM) from the plurality of signals; and

displaying the intrinsic rhythm BSPM on a graphical user interface.

19. A system of cardiac pacing comprising:

processing means for determining a baseline rhythm, the baseline rhythm includes a baseline atrial event and a baseline right ventricular (RV) event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of activation times determined from a plurality of body-surface electrodes;

processing means for determining whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times;

processing means for applying a correction factor to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the time interval measured from the atrial event to the RV event is disparate from the time interval measured from the atrial event to the earliest RV activation time; and

processing means for configuring the processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before the RV sensing time.

20. The system of claim 19 wherein the atrial event is acquired from one of an implanted cardiac lead or a leadless device, the atrial event being sensed from an atrial pace or an intrinsic atrial event.

21. The system of claim 19 wherein the atrial event includes onset of a depolarization acquired through a surface ECG electrode.

22. The system of claim 19 wherein the correction factor is based on the difference between the RV event and the earliest RV activation time.

23. The system of claim 22 wherein the pre-excitation interval is a time-interval defined by electrical stimuli delivered to the left ventricle (LV) before sensing the RV event.

24. The system of claim 19 further comprising:

processing means for determining whether a RV lead is positioned in an area that is electrically late in activation.

25. The system of claim 24 wherein the electrically late area activates later than 40-60 ms after onset of depolarization.

26. The system of claim 24 wherein delivery of left ventricular pacing pulses is timed to occur 50-60 ms before RV event.

27. The system of claim 24 wherein delivery of left ventricular pacing pulses is timed to occur 40-70 ms before RV event.

28. The system of claim 19 wherein disparate is defined as the earliest RV activation time which is about 40-300 ms ahead of the earliest sensed RV event.

29. The system of claim 28 wherein the earliest RV activation time is defined by an earliest activation time on right-sided electrodes among a plurality of activation times measured from a plurality of ECG electrodes on the torso surface.

30. The system of claim 28 wherein the earliest RV activation time is defined by a timing of onset of a far-field RV electrogram measured from the device.

31. The system of claim 29 wherein each of the plurality of activation times are determined by a timing of a steepest negative slope on the unipolar ECG signal from each of a plurality of surface electrodes and a common fiducial point.

32. The system of claim 31 wherein the common fiducial point is the onset of depolarization (Q-point) measured from a surface ECG electrode or timing of an atrial event as sensed by an implantable medical device.

33. A system of cardiac pacing comprising:

processing means for determining a baseline rhythm, the baseline rhythm includes a baseline atrial event and a baseline right ventricular (RV) event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of activation times determined from a plurality of body-surface electrodes;

processing means for determining whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times;

processing means for applying a correction factor to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the time interval measured from an atrial event to the RV event is disparate from the time interval measured from the atrial event to the earliest RV activation time; and

processing means for configuring the processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before the RV sensing time, wherein disparate is defined as the earliest RV activation time which is about 40-300 ms ahead of the earliest sensed RV event.

34. A system of cardiac pacing comprising:

processing means for determining a baseline rhythm, the baseline rhythm includes a baseline atrial event and a baseline right ventricular (RV) event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of activation times determined from a plurality of body-surface electrodes;

processing means for determining whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times;

processing means for applying a correction factor to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the time interval measured from an atrial event to the RV event is disparate from the time interval measured from the atrial event to the earliest RV activation time; and

processing means for configuring the processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before the RV sensing time, wherein disparate is defined as the earliest RV activation time which is about 40-300 ms ahead of the earliest sensed RV event, wherein each of the plurality of activation times are determined by a timing of a steepest negative slope on the unipolar ECG signal from each of a plurality of surface electrodes and a common fiducial point,

wherein the common fiducial point is the onset of depolarization (Q-point) measured from a surface ECG electrode or timing of an atrial event as sensed by an implantable medical device.