Method and system for improved estimation of time of left ventricular pacing with respect to intrinsic right ventricular activation in cardiac resynchronization therapy

• US 9,265,955 B2
• Filed: 07/26/2013
• Issued: 02/23/2016
• Est. Priority Date: 07/26/2013
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ghosh, Subham
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US13/952,061
• Publication Number:
  US 20150032173A1
• Time in Patent Office: 942 Days
• Field of Search: 607/2, 607/9, 607/123, 607/25
• US Class Current: 1/1
• CPC Class Codes: A61B 5/1102 Ballistocardiography
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/29 for permanent or long-term implantation
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A method and system of cardiac pacing is disclosed. A baseline rhythm is determined. The baseline rhythm includes a baseline atrial event and a baseline right ventricular RV event from an implanted cardiac lead or a leadless device, a pre-excitation interval determined from the baseline atrial event and the baseline RV event, and a plurality of activation times determined from a plurality of body-surface electrodes. A determination is made as to whether a time interval measured from an atrial event to a RV event is disparate from another time interval measured from the atrial event to an earliest RV activation time of the plurality of activation times. A correction factor is applied to the pre-excitation interval to obtain a corrected pre-excitation interval in response to determining the RV event is disparate from the earliest RV activation time. The processor is configured to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before RV sensing time.

Claims

1. A method of cardiac pacing using an implanted pulse generator comprising:

a) determining a baseline rhythm including a baseline atrial event and a baseline right ventricular (RV) event from one or more implanted electrodes coupled to the pulse generator;

b) determining a pre-excitation interval from the baseline atrial event and the baseline RV event;

c) using a body surface electrode to acquire an earliest time of RV activation (T1) in an intrinsic rhythm;

d) using an implanted electrode to acquire an intrinsic rhythm activation time (T2);

e) determining an offset defined as a difference between T2 and T1;

f) applying a correction factor to the pre-excitation interval for LV only pacing based on the offset; and

g) configuring a processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before RV sensing time.

2. The method of claim 1 further comprising:

determining an offset, the offset defined as activation time of an electrode (T2)—

minus an earliest time of activation (T1); and

setting a timing of LV pacing with respect to an RV sensing electrode based on the offset T2-T1.

3. The method of claim 1 further comprising:

determining whether the offset is a substantially large offset.

4. The method of claim 1 further comprising:

delivering LV pacing substantially earlier than RV sense in response to determining the offset is substantially large.

5. The method of claim 4 wherein the offset is substantially large provided the offset is greater than a value which ranges from 20 ms to 50 ms.

6. The method of claim 1 wherein each of the plurality of activation times are determined by a timing of a steepest negative slope on an unipolar ECG signal from each of a plurality of surface electrodes and a common fiducial point.

7. The method of claim 6 wherein the common fiducial point is an onset of depolarization (Q-point) measured from a surface ECG electrode or timing of an atrial event as sensed by an implantable medical device.

8. System of cardiac pacing using an implanted pulse generator comprising:

a) means for determining a baseline rhythm including a baseline atrial event and a baseline right ventricular (RV) event from one or more electrodes;

b) determining a pre-excitation interval from the baseline atrial event and the baseline RV event;

c) using a body surface electrode to acquire an earliest time of RV activation (T1) in an intrinsic rhythm;

d) using an implanted electrode to acquire an intrinsic rhythm activation time (T2);

e) determining an offset defined as a difference between T2 and T1;

f) applying a correction factor to the pre-excitation interval for LV only pacing based on the offset; and

g) configuring a processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before RV sensing time.

9. The system of claim 8 further comprising:

determining an offset, the offset defined as activation time of an electrode (T2)—

minus an earliest time of activation (T1); and

setting a timing of LV pacing with respect to an RV sensing electrode based on the offset T2-T1.

10. The system of claim 8 further comprising:

processing means for determining whether the offset is a substantially large offset.

11. The system of claim 8 further comprising:

delivering means for delivering LV pacing substantially earlier than RV sense in response to determining the offset is substantially large.

12. The system of claim 11 wherein the offset is substantially large provided the offset is greater than a value which ranges from 20 ms to 50 ms.

13. The system of claim 8 wherein each of the plurality of activation times are determined by a timing of a steepest negative slope on an unipolar ECG signal from each of a plurality of surface electrodes and a common fiducial point.

14. The system of claim 13 wherein the common fiducial point is an onset of depolarization (Q-point) measured from a surface ECG electrode or timing of an atrial event as sensed by an implantable medical device.

15. A non-transitory, computer-readable storage medium comprising instructions that, when executed, cause a processor to perform a method comprising:

a) determining a baseline rhythm including a baseline atrial event and a baseline right ventricular (RV) event from one or more electrodes;

b) determining a pre-excitation interval from the baseline atrial event and the baseline RV event;

c) using a body surface electrode to acquire an earliest time of RV activation (T1) in an intrinsic rhythm;

d) using an implanted electrode to acquire an intrinsic rhythm activation time (T2);

e) determining an offset defined as a difference between T2 and T1;

f) applying a correction factor to the pre-excitation interval for LV only pacing based on the offset; and

g) configuring a processor to signal the pulse generator to deliver electrical stimuli to a left ventricle (LV) using the corrected pre-excitation interval before RV sensing time.

16. The medium of claim 15 wherein the method further comprising:

determining an offset, the offset defined as activation time of an electrode (T2)—

minus an earliest time of activation (T1); and

setting a timing of LV pacing with respect to an RV sensing electrode based on the offset T2-T1.

17. The medium of claim 15 wherein the method further comprising:

determining whether the offset is a substantially large offset.

18. The medium of claim 15 wherein the method further comprising:

delivering LV pacing substantially earlier than RV sense in response to determining the offset is substantially large.

19. The medium of claim 18 wherein the offset is substantially large provided the offset is greater than a value which ranges from 20 ms to 50 ms.

20. The system of claim 19 wherein each of the plurality of activation times are determined by a timing of a steepest negative slope on an unipolar ECG signal from each of a plurality of surface electrodes and a common fiducial point.

21. The system of claim 20 wherein the common fiducial point is an onset of depolarization (Q-point) measured from a surface ECG electrode or timing of an atrial event as sensed by an implantable medical device.