Nanoliter array loading
First Claim
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1. A system for holding a plurality of biomolecular samples, comprising:
- a receptacle comprising a plurality of wells disposed within a substrate;
a plurality of sample chips disposed inside respective wells of the receptacle, each chip comprising an array of sample wells anda loader interface structure comprising an upper portion and a lower portion, the lower portion configured to hold the sample chips, wherein the upper portion is disposed above the plurality of wells of the receptacle while the lower portion is disposed inside at least some of the plurality of wells of the receptacle.
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Abstract
An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
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Citations
17 Claims
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1. A system for holding a plurality of biomolecular samples, comprising:
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a receptacle comprising a plurality of wells disposed within a substrate; a plurality of sample chips disposed inside respective wells of the receptacle, each chip comprising an array of sample wells and a loader interface structure comprising an upper portion and a lower portion, the lower portion configured to hold the sample chips, wherein the upper portion is disposed above the plurality of wells of the receptacle while the lower portion is disposed inside at least some of the plurality of wells of the receptacle. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A kit for holding a plurality of biomolecular samples, comprising:
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a receptacle comprising a plurality of wells disposed within a substrate; a plurality of sample chips, each chip comprising an array of sample wells; the plurality of sample chips configured to fit inside respective wells of the receptacle and a loader interface structure comprising an upper portion and a lower portion, the lower portion configured to hold the sample chips, wherein during use the upper portion is disposed above the plurality of wells of the receptacle while the lower portion is disposed inside at least some of the plurality of wells of the receptacle. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method for holding a plurality of biomolecular samples, comprising:
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providing a receptacle comprising a plurality of wells disposed within a substrate; providing a loader interface structure comprising an upper portion and a lower portion, the lower portion holding a plurality of sample chips; and placing the plurality of sample chips inside respective wells of the receptacle, each chip comprising an array of through-hole sample wells wherein placing the plurality of chips comprises locating the upper portion above the plurality of wells of the receptacle and locating the lower portion inside at least some of the plurality of wells of the receptacle. - View Dependent Claims (16, 17)
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Specification