Method and system for patient-specific modeling of blood flow

• US 9,271,657 B2
• Filed: 03/21/2014
• Issued: 03/01/2016
• Est. Priority Date: 08/12/2010
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: Taylor, Charles A.
• Primary Examiner(s): Clow, Lori A
• Application Number:
  US14/222,439
• Publication Number:
  US 20140207432A1
• Time in Patent Office: 711 Days
• Field of Search: None
• US Class Current: 1/1
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Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.

Claims

1. A system for determining cardiovascular information for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific image data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;

create a three-dimensional model representing at least the portion of the one or more coronary arteries, using the received patient-specific image data;

create, using the three-dimensional model, a blood flow model relating to a blood flow characteristic within the portion of the one or more coronary arteries, the blood flow model including one or more equations of blood flow and one or more boundary conditions of the blood flow;

modify the one or more boundary conditions using the patient-specific image data;

determine a value of the blood flow characteristic at each of a plurality of locations of the portion of the one or more coronary arteries by solving one or more equations of the blood flow model using the one or more modified boundary conditions; and

display a representation of the portion of the one or more coronary arteries, wherein the determined values of the blood flow characteristic are indicated on the display of respective locations of the one or more coronary arteries using at least one visual indicator.

2. The system of claim 1, wherein the visual indicator comprises at least a color gradient, a shading, or a graphical indicator.

3. The system of claim 1, wherein the display of the portion of the one or more coronary arteries is accompanied by a scale indicating at least one numerical value associated with the at least one visual indicator.

4. The system of claim 1, wherein the modification of the one or more boundary conditions comprises determining the one or more boundary conditions based on the patient-specific image data.

5. The system of claim 1, wherein changes in the blood flow characteristic are indicated by changes in color or shading of the at least one visual indicator.

6. The system of claim 1, wherein the visual indicator corresponds to a value of the blood flow characteristic that meets a predetermined threshold of functional significance, wherein the functional significance comprises a measure of impact of a lesion on blood flow.

7. The system of claim 1, wherein the blood flow characteristic comprises a fractional flow reserve, and wherein the visual indicator corresponds to a lowest value of the fractional flow reserve in the portion of the one or more coronary arteries.

8. The system of claim 1, wherein the blood flow characteristic comprises a fractional flow reserve, and wherein the visual indicator is displayed, corresponding to a lowest value of the fractional flow reserve, for each of the one or more coronary arteries.

9. The system of claim 1, wherein the blood flow characteristic is a fractional flow reserve, blood flow velocity, blood pressure, or blood flow rate.

10. The system of claim 1, wherein the blood flow model is created based at least in part on modeling a condition of hyperemia, a condition of rest, or a condition of exercise.

11. The system of claim 1, wherein:

the blood flow characteristic comprises a fractional flow reserve;

the fractional flow reserve indicates a ratio between a blood flow or pressure at a first location in the one or more coronary arteries and a blood flow or pressure at a second location upstream from the first location; and

the at least one computer system is configured to determine the fractional flow reserve at a plurality of locations in the one or more coronary arteries.

12. The system of claim 1, wherein the at least one visual indicator comprises a color gradient displayed such that the determined values of the blood flow characteristic that meet a predetermined threshold are depicted as red.

13. A method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:

receiving patient-specific image data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;

creating a three-dimensional model representing at least the portion of the one or more coronary arteries, using the received patient-specific image data;

creating, using the three-dimensional model, a blood flow model relating to a blood flow characteristic within the portion of the one or more coronary arteries, the blood flow model including one or more equations of blood flow and one or more boundary conditions of the blood flow;

modifying the one or more boundary conditions using the patient-specific image data;

determining a value of the blood flow characteristic at each of a plurality of locations of the portion of the one or more coronary arteries by solving one or more equations of the blood flow model using the one or more modified boundary conditions; and

displaying a representation of the portion of the one or more coronary arteries, wherein the determined values of the blood flow characteristic are indicated on the display of respective locations of the one or more coronary arteries using at least one visual indicator.

14. The method of claim 13, wherein the visual indicator comprises at least a color gradient, a shading, or a graphical indicator.

15. The method of claim 13, wherein modifying the one or more boundary conditions comprises determining the one or more boundary conditions based on the patient-specific image data.

16. A system for determining cardiovascular information for a patient, the system comprising:

at least one computer system configured to;

receive patient-specific image data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;

create a three-dimensional model representing at least the portion of the one or more coronary arteries, using the received patient-specific image data;

create, using the three-dimensional model, a blood flow model relating to a blood flow characteristic within the portion of the one or more coronary arteries using, at least in part, a mass or a volume of myocardial tissue;

modify the blood flow model using the patient-specific image data;

determine a value of the blood flow characteristic at each of a plurality of locations of the portion of the one or more coronary arteries using the modified blood flow model; and

display a representation of the portion of the one or more coronary arteries, wherein the determined values of the blood flow characteristic are indicated on the display of respective locations of the one or more coronary arteries using at least one visual indicator.

17. The system of claim 16, wherein the visual indicator comprises at least a color gradient, a shading, or a graphical indicator.

18. The system of claim 16, wherein the display of the portion of the one or more coronary arteries is accompanied by a scale indicating at least one numerical value associated with the at least one visual indicator.

19. The system of claim 16, wherein the modification of the blood flow model comprises determining the blood flow model based on the patient-specific image data.

20. The system of claim 16, wherein changes in the blood flow characteristic are indicated by changes in color or shading of the at least one visual indicator.

21. The system of claim 16, wherein the visual indicator corresponds to a value of the blood flow characteristic that meets a predetermined threshold of functional significance, wherein the functional significance comprises a measure of impact of a lesion on blood flow.

22. The system of claim 16, wherein the blood flow characteristic comprises a fractional flow reserve, and wherein the visual indicator corresponds to a lowest value of the fractional flow reserve in the portion of the one or more coronary arteries.

23. The system of claim 16, wherein the blood flow characteristic comprises a fractional flow reserve, and wherein the visual indicator is displayed, corresponding to a lowest value of the fractional flow reserve, for each of the one or more coronary arteries.

24. The system of claim 16, wherein the blood flow characteristic is a fractional flow reserve, blood flow velocity, blood pressure, or blood flow rate.

25. The system of claim 16, wherein the blood flow model is created by, at least in part, modeling a condition of hyperemia, a condition of rest, or a condition of exercise.

26. The system of claim 16, wherein:

the blood flow characteristic comprises a fractional flow reserve;

the fractional flow reserve indicates a ratio between a blood flow or pressure at a first location in the one or more coronary arteries and a blood flow or pressure at a second location upstream from the first location; and

the at least one computer system is configured to determine the fractional flow reserve at a plurality of locations in the one or more coronary arteries.

27. The system of claim 16, wherein the at least one visual indicator comprises a color gradient displayed such that the determined values of the blood flow characteristic that meet a predetermined threshold are depicted as red.

28. A method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:

receiving patient-specific image data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of one or more coronary arteries;

creating a three-dimensional model representing at least the portion of the one or more coronary arteries, using the received patient-specific image data;

creating, using the three-dimensional model, a blood flow model relating to a blood flow characteristic within the portion of the one or more coronary arteries using, at least in part, a mass or a volume of myocardial tissue;

modify the blood flow model using the patient-specific image data;

determine a value of the blood flow characteristic at each of a plurality of locations of the portion of the one or more coronary arteries using the modified blood flow model; and

display a representation of the portion of the one or more coronary arteries, wherein the determined values of the blood flow characteristic are indicated on the display of respective locations of the one or more coronary arteries using at least one visual indicator.

29. The method of claim 28, wherein the visual indicator comprises at least a color gradient, a shading, or a graphical indicator.

30. The method of claim 28, wherein the modification of the blood flow model comprises determining the blood flow model based on the patient-specific image data.