Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
First Claim
1. A non-invasive method for measuring blood flow distribution in principal vessels of a heart of a subject, the method comprising:
- passively illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm and a field of view including the region of interest is at least about 2 square centimeters;
sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject and the acquisition being triggered by the motion of the heart of the subject; and
electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow speed in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image.
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Accused Products
Abstract
A non-invasive method for measuring blood flow in principal vessels of a heart of a subject is provided. The method includes illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow rate in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image.
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Citations
38 Claims
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1. A non-invasive method for measuring blood flow distribution in principal vessels of a heart of a subject, the method comprising:
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passively illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm and a field of view including the region of interest is at least about 2 square centimeters; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject and the acquisition being triggered by the motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow speed in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 35, 36, 37, 38)
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15. A non-invasive method for measuring blood flow distribution in principal vessels of a subject, the method comprising:
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passively illuminating a region of interest with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm and a field of view including the region of interest is at least about 2 square centimeters; sequentially acquiring at least two speckle images of the region of interest during a fixed time period; electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow speed in the principal vessels and quantify perfusion distribution in tissue in the region of interest from the LSCI image; calculating a velocity field for the region of interest; calculating blood flow rate distribution in the region of interest based on the calculated velocity field; and comparing the calculated blood flow speed in the region of interest to the blood flow speed determined using the acquired at least two speckle images of the region of interest to verify results obtained using the at least two speckle images. - View Dependent Claims (16, 17)
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18. A non-invasive system for measuring blood flow distribution in principal vessels in a heart of a subject, the system comprising:
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a coherent light source configured to passively illuminate a region of interest in the heart of the subject, the coherent light source having a wavelength of from about 600 nm to about 1100 and a field of view including the region of interest is at least about 2 square centimeters; a camera in communication with the coherent light source that is configured to sequentially acquire at least two speckle images of the region of interest in the heart during a fixed time period, wherein acquisition of the at least two speckle images is synchronized with and trigger by motion of the heart of the subject; and a data processing circuit configured to evaluate the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow speed in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A computer program product for measuring blood flow distribution in principal vessels in a heart of a subject, the computer program product comprising:
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a non-transitory computer-readable storage medium having computer-readable program code embodied in the medium, the computer-readable program code comprising; computer readable program code configured to electronically evaluate temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow speed in the principal vessels and perfusion distribution in tissue in a region of interest in the heart from the LSCI image, wherein and a field of view including the region of interest is at least about 2 square centimeters and the at least two speckle images are sequentially acquired using a camera during a fixed time period when the region of interest of the subject is passively illuminated by a coherent light source having a wavelength of from about 600 nm to about 1100 nm; and computer readable program code configured to sequentially acquire the at least two speckle images in synchronization with motion of the heart of the subject trigger the acquisition responsive to the motion of the heart of the subject. - View Dependent Claims (33, 34)
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Specification